The ratio of full length IgY to truncated IgY in immune complexes affects macrophage phagocytosis and the acute phase response of mallard ducks ( Anas platyrhynchos)

Ducks produce a full length IgY and a truncated isoform (IgYΔFc). IgY and IgY(ΔFc) were isolated from ducks vaccinated against Escherichia coli and used to make E.coli-Ig immune complexes (IC). Phagocytosis of IC by duck monocytes decreased directly with the proportion of IgYΔFc ( p

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Bibliographic Details
Published in:Developmental and comparative immunology 2004-06, Vol.28 (7), p.665-672
Main Authors: Humphrey, Brooke D, Calvert, Chris C, Klasing, Kirk C
Format: Article
Language:English
Subjects:
Acute phase response
Acute-Phase Reaction - immunology
Animals
Antigen-Antibody Complex - immunology
Duck
Ducks - genetics
Ducks - immunology
Escherichia coli - immunology
Hemopexin
Hemopexin - immunology
IgY
IgY(ΔFc)
Immune complex
Immunoglobulins - genetics
Immunoglobulins - immunology
Interleukin-1 - immunology
Interleukin-1β
Liver - immunology
Macrophages - cytology
Macrophages - immunology
Phagocytosis
Phagocytosis - immunology
Spleen - immunology
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Description
Summary:Ducks produce a full length IgY and a truncated isoform (IgYΔFc). IgY and IgY(ΔFc) were isolated from ducks vaccinated against Escherichia coli and used to make E.coli-Ig immune complexes (IC). Phagocytosis of IC by duck monocytes decreased directly with the proportion of IgYΔFc ( p
ISSN:0145-305X
1879-0089
DOI:10.1016/j.dci.2003.11.003