Interleukin-10 and related cytokines and receptors

The Class 2 alpha-helical cytokines consist of interleukin-10 (IL-10), IL-19, IL-20, IL-22, IL-24 (Mda-7), and IL-26, interferons (IFN-alpha, -beta, -epsilon, -kappa, -omega, -delta, -tau, and -gamma) and interferon-like molecules (limitin, IL-28A, IL-28B, and IL-29). The interaction of these cytoki...

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Bibliographic Details
Published in:Annual review of immunology 2004-01, Vol.22, p.929-979
Main Authors: Pestka, Sidney, Krause, Christopher D, Sarkar, Devanand, Walter, Mark R, Shi, Yufang, Fisher, Paul B
Format: Article
Language:English
Subjects:
Animals
Cytokines - chemistry
Cytokines - physiology
Humans
Interleukin-10 - chemistry
Interleukin-10 - physiology
Phylogeny
Receptors, Cytokine - chemistry
Receptors, Cytokine - physiology
Signal Transduction - immunology
Species Specificity
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Summary:The Class 2 alpha-helical cytokines consist of interleukin-10 (IL-10), IL-19, IL-20, IL-22, IL-24 (Mda-7), and IL-26, interferons (IFN-alpha, -beta, -epsilon, -kappa, -omega, -delta, -tau, and -gamma) and interferon-like molecules (limitin, IL-28A, IL-28B, and IL-29). The interaction of these cytokines with their specific receptor molecules initiates a broad and varied array of signals that induce cellular antiviral states, modulate inflammatory responses, inhibit or stimulate cell growth, produce or inhibit apoptosis, and affect many immune mechanisms. The information derived from crystal structures and molecular evolution has led to progress in the analysis of the molecular mechanisms initiating their biological activities. These cytokines have significant roles in a variety of pathophysiological processes as well as in regulation of the immune system. Further investigation of these critical intercellular signaling molecules will provide important information to enable these proteins to be used more extensively in therapy for a variety of diseases.
ISSN:0732-0582
1545-3278
DOI:10.1146/annurev.immunol.22.012703.104622