Intracerebroventricular injection of murine leptin enhances the postprandial metabolic rate in the rat

Energy balance is achieved by means of a concomitant control of both food intake and energy expenditure. Leptin, synthesized in the adipose tissue, acts on brain structures and lowers body weight by inhibiting food intake and in parallel by enhancing energy expenditure i.e. metabolism or one of its...

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Bibliographic Details
Published in:Brain research 2000-08, Vol.874 (1), p.30-36
Main Authors: Ruffin, Marie-Pierre, Nicolaidis, Stylianos
Format: Article
Language:English
Subjects:
Animals
Background metabolism
Behavior, Animal - drug effects
Biological and medical sciences
Body weight
Body Weight - drug effects
Eating - drug effects
Feeding
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Injections, Intraventricular
Leptin - pharmacology
Lipolysis
Male
Metabolism - drug effects
Mice
Motor Activity - drug effects
Obesity
Postprandial Period
Rats
Rats, Sprague-Dawley
Respiration - drug effects
Respiratory quotient
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Energy balance is achieved by means of a concomitant control of both food intake and energy expenditure. Leptin, synthesized in the adipose tissue, acts on brain structures and lowers body weight by inhibiting food intake and in parallel by enhancing energy expenditure i.e. metabolism or one of its components. Recording distinctly these components allowed us to assess the effect of an acute intracerebroventricular injection of leptin on both feeding pattern and background metabolism (i.e. energy expenditure free from the part of locomotor activity), respiratory quotient, feeding-related metabolism and locomotor activity-related metabolism. Leptin injection to Sprague–Dawley male rats induced an inhibition of feeding that began 90 min after the treatment and lasted 1 h before to return to the control feeding pattern level. Considering this late behavioral effect, it appeared that leptin may act during the postprandial period so that we recorded the different metabolic parameters following a 3 g calibrated meal itself preceded by leptin vs. artificial cerebrospinal fluid injection. Postprandial respiratory quotient was rapidly lowered in leptin-treated animals and subsequent background metabolism increased for 6 h. Thus it appeared that leptin increased the duration of the postprandial metabolic rate via the recruitment of endogenous fat stores. Enhancement in the thermic effect of food may be the reason for feeding behavior inhibition to be delayed.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(00)02570-1