Multichannel near-infrared spectroscopy in depression and schizophrenia: cognitive brain activation study

Recent developments in near-infrared spectroscopy (NIRS) have enabled the noninvasive clarification of brain functions in psychiatric disorders with measurement of hemoglobin concentrations as cerebral blood volume. Ten patients with depression, 13 patients with schizophrenia, and 16 age- and gender...

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Bibliographic Details
Published in:Biological psychiatry (1969) 2004-03, Vol.55 (5), p.501-511
Main Authors: Suto, Tomohiro, Fukuda, Masato, Ito, Makoto, Uehara, Toru, Mikuni, Masahiko
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Analysis of Variance
Biological and medical sciences
Brain Mapping - instrumentation
Brain Mapping - methods
cerebral blood volume
Cerebrovascular Circulation
Cognition - physiology
Depression
Depressive Disorder, Major - diagnosis
Depressive Disorder, Major - metabolism
diagnosis
Female
Frontal Lobe - blood supply
Frontal Lobe - metabolism
Humans
Male
Matched-Pair Analysis
Medical sciences
Middle Aged
Mood disorders
Near-infrared spectroscopy
Oxyhemoglobins - metabolism
Psychology. Psychoanalysis. Psychiatry
Psychomotor Performance - physiology
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - diagnosis
Schizophrenia - metabolism
Spectroscopy, Near-Infrared
Temporal Lobe - blood supply
Temporal Lobe - metabolism
Verbal Behavior - physiology
word fluency test
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Summary:Recent developments in near-infrared spectroscopy (NIRS) have enabled the noninvasive clarification of brain functions in psychiatric disorders with measurement of hemoglobin concentrations as cerebral blood volume. Ten patients with depression, 13 patients with schizophrenia, and 16 age- and gender-matched healthy control subjects participated in the study after giving consent. The relative concentrations of oxyhemoglobin [oxyHb] were measured with frontal and temporal probes every .1 sec during word fluency and unilateral finger tapping tasks, with two 24-channel NIRS machines. The [oxyHb] increase patterns during the word fluency task varied among the three groups, although their task performances were similar: the depression group was characterized by a smaller [oxyHb] increase during the first half of the task period and the schizophrenic group by a small trough of [oxyHb] at the start of the task period and [oxyHb] re-increase in the posttask period. [OxyHb] increases during the finger-tapping task were rather larger in the patient groups than in the control group. The characteristic time courses of [oxyHb] changes in the frontal lobe were elucidated for depression and schizophrenia. Near-infrared spectroscopy, with its noninvasiveness and high time resolution, can be a useful tool for research and clinical purposes in psychiatry.
ISSN:0006-3223
1873-2402
DOI:10.1016/j.biopsych.2003.09.008