Expression of regenerating gene I in gastric adenocarcinomas: Correlation with tumor differentiation status and patient survival

Regenerating gene I (REG) was identified as a growth factor for pancreatic islet beta cells. Enhanced REG expression was observed during the healing of gastric mucosa. REG expression was observed in various tumors including gastric carcinoma, but to the authors' knowledge, the correlation betwe...

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Published in:Cancer 2004-03, Vol.100 (6), p.1130-1136
Main Authors: DIPOK KUMAR DHAR, UDAGAWA, Jun, NAGASUE, Naofumi, ISHIHARA, Shunji, OTANI, Hiroki, KINOSHITA, Yoshikazu, TAKASAWA, Shin, OKAMOTO, Hiroshi, KUBOTA, Hirofumi, FUJII, Toshiyuki, TACHIBANA, Mitsuo
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adult
Aged
Biological and medical sciences
Blotting, Northern
Calcium-Binding Proteins - biosynthesis
Calcium-Binding Proteins - genetics
Female
Humans
Immunohistochemistry
In Situ Hybridization
Lithostathine
Male
Medical sciences
Middle Aged
Neoplasm Staging
Nerve Tissue Proteins
Prognosis
RNA, Messenger - analysis
Stomach Neoplasms - metabolism
Stomach Neoplasms - mortality
Stomach Neoplasms - pathology
Tumors
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Summary:Regenerating gene I (REG) was identified as a growth factor for pancreatic islet beta cells. Enhanced REG expression was observed during the healing of gastric mucosa. REG expression was observed in various tumors including gastric carcinoma, but to the authors' knowledge, the correlation between REG expression and clinicopathologic characteristics and patient prognosis have not been evaluated. The REG messenger RNA level was analyzed by Northern blot analysis and localization was performed by in situ hybridization and immunohistochemistry in gastric adenocarcinoma specimens. The correlations between REG expression and clinicopathologic features and survival of the patients were analyzed. Of the 68 patients studied, 24 (35%) were positive for REG. There was a significant consistency in the intensity and localization of REG transcript and protein expressions. REG expression was enhanced in advanced T classification tumors and in tumors that were not well differentiated. A significant number of metastatic lymph nodes were present in REG-positive tumors. Overall and disease-free survival were found to be poor for patients with REG-positive tumors. REG expression was reported to be an independent predictor of overall patient survival. Determination of REG expression may help to identify aggressive gastric tumors and to tailor appropriate therapy for patients with REG-positive tumors.
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.20097