Bioactivity of tape cast and sintered bioactive glass-ceramic in simulated body fluid

A common ceramic processing technique, tape casting, was used to produce thin, flexible sheets of bioactive glass (Bioglass ® 45S5) particulate in an organic matrix. Tape casting offers the possibility of producing three-dimensional shapes, as the final material is built up layer by layer. Bioactive...

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Bibliographic Details
Published in:Biomaterials 2002-06, Vol.23 (12), p.2599-2606
Main Authors: Clupper, Daniel C., Mecholsky, John J., LaTorre, Guy P., Greenspan, David C.
Format: Article
Language:English
Subjects:
Bioactive glass-ceramic
Biocompatible Materials - chemistry
Body fluids
Body Fluids - chemistry
Casting
Ceramics - chemistry
Crystalline materials
Crystallization
Energy dispersive spectroscopy
FTIR
Glass
Glass ceramics
Hydroxyapatite
Hydroxyapatites - chemistry
Microscopy, Electron, Scanning
SBF
Scanning electron microscopy
Sintering
Spectroscopy, Fourier Transform Infrared
Surface reactions
Tape casting
Tapes
X-Ray Diffraction
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Summary:A common ceramic processing technique, tape casting, was used to produce thin, flexible sheets of bioactive glass (Bioglass ® 45S5) particulate in an organic matrix. Tape casting offers the possibility of producing three-dimensional shapes, as the final material is built up layer by layer. Bioactive glass tapes were sintered together to form small discs for in vitro bioactivity testing in simulated body fluid (SBF). Four different sintering schedules were investigated: 800, 900, and 1000°C for 3 h; and 1000°C for 6 h. Each schedule produced a crystalline material of major phase Na 2Ca 2Si 3O 9. Tape cast and sintered bioactive glass-ceramic processed at 1000°C formed crystalline hydroxyapatite layers after 20–24 h in SBF as indicated by Fourier transform infrared spectroscopy, Scanning electron microscopy, and EDS data. FTIR revealed that the greatest amount of hydroxyapatite formation after 2 h was observed for samples sintered at 900°C. The differences in bioactive response were likely caused by the variation in the extent of sintering and, consequently, the amount of surface area available for reaction with SBF.
ISSN:0142-9612
1878-5905
DOI:10.1016/S0142-9612(01)00398-2