High Concentrations of Keratinocyte Growth Factor in Airways of Premature Infants Predicted Absence of Bronchopulmonary Dysplasia

Premature lungs are highly susceptible to lung injuries, leading to bronchopulmonary dysplasia (BPD). Keratinocyte growth factor (KGF) is produced by the developing lung and may reduce the risk of BPD by preventing injury to the lung epithelium and enhancing its repair. To determine whether KGF conc...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2002-05, Vol.165 (10), p.1384-1387
Main Authors: Danan, Claude, Franco, Marie-Laure, Jarreau, Pierre-Henri, Dassieu, Gilles, Chailley-Heu, Bernadette, Bourbon, Jacques, Delacourt, Christophe
Format: Article
Language:English
Subjects:
Analysis of Variance
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Biomarkers - analysis
Bronchoalveolar Lavage Fluid - cytology
Bronchopulmonary Dysplasia - blood
Bronchopulmonary Dysplasia - diagnosis
Bronchopulmonary Dysplasia - mortality
Emergency and intensive care: neonates and children. Prematurity. Sudden death
Enzyme-Linked Immunosorbent Assay
Female
Fibroblast Growth Factor 7
Fibroblast Growth Factors - analysis
Humans
Infant, Newborn
Infant, Premature
Intensive care medicine
Male
Medical sciences
Predictive Value of Tests
Probability
Prognosis
Prospective Studies
Respiratory Function Tests
Sampling Studies
Sensitivity and Specificity
Survival Analysis
Trachea - cytology
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Summary:Premature lungs are highly susceptible to lung injuries, leading to bronchopulmonary dysplasia (BPD). Keratinocyte growth factor (KGF) is produced by the developing lung and may reduce the risk of BPD by preventing injury to the lung epithelium and enhancing its repair. To determine whether KGF concentrations in the airways during the initial phase of hyaline membrane disease are correlated with subsequent development of BPD defined as the need for supplemental oxygen at a postconceptional age of 36 weeks, we obtained tracheal aspirates within 3 hours of birth (Day 0) from 91 intubated neonates with a gestational age of 30 weeks or less. Repeat samples were obtained from 42 neonates within 5 days after birth. KGF in aspirate supernatants was measured by enzyme-linked immunosorbent assay. On Day 0, KGF was detected in all but six neonates. A significant increase in KGF concentration was found from the first to the second samples. The highest KGF concentration within 5 days after birth (KGF(max)) was significantly higher in survivors without BPD than in those with BPD. A KGF(max) value higher than 110 pg/ml had a positive predictive value of 95% for absence of BPD. KGF may hold promise for the treatment of very premature neonates.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.200112-134BC