Continuous cytomegalovirus seroconversion in a large group of healthy blood donors

Background and Objectives  Transmission of cytomegalovirus (CMV) to seronegative, immunocompromised recipients can cause serious and fatal complications. Although the seroprevalence of CMV is high, the risk of primary CMV infection among healthy blood donors has not yet been analysed in a large popu...

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Bibliographic Details
Published in:Vox sanguinis 2004-01, Vol.86 (1), p.41-44
Main Authors: Hecker, M., Qiu, D., Marquardt, K., Bein, G., Hackstein, H.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Algorithms
Blood Donors
CMV
Cytomegalovirus Infections - epidemiology
Cytomegalovirus Infections - transmission
epidemiology
Female
Humans
infection
Male
Middle Aged
Probability
Risk
seroconversion
Seroepidemiologic Studies
Sex Factors
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Summary:Background and Objectives  Transmission of cytomegalovirus (CMV) to seronegative, immunocompromised recipients can cause serious and fatal complications. Although the seroprevalence of CMV is high, the risk of primary CMV infection among healthy blood donors has not yet been analysed in a large population. Materials and Methods  We developed an algorithm to determine the rate of CMV seroconversion in an overall cohort of 24 260 subjects who donated 176 474 blood units during an 11‐year observation period. Results  We detected CMV seroconversion in all relevant age groups (18–60 years) with an overall seroconversion rate of 0·55% per year. Both CMV seroconversion and seroprevalence occurred more frequently in female donors (P = 0·02 and P 
ISSN:0042-9007
1423-0410
DOI:10.1111/j.0042-9007.2004.00388.x