Evolution of diaschisis in a focal stroke model

Stroke produces diaschisis in adjacent and connected regions. The sequential changes in diaschisis over time and the relationship of regions of diaschisis to functional cortical areas and regions of poststroke neuroplasticity have not been determined. Small cortical strokes were produced in the barr...

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Bibliographic Details
Published in:Stroke (1970) 2004-03, Vol.35 (3), p.758-763
Main Authors: CARMICHAEL, S. Thomas, TATSUKAWA, Keith, KATSMAN, Diana, TSUYUGUCHI, Naohiro, KORNBLUM, Harley I
Format: Article
Language:English
Subjects:
Animals
Antipyrine - analogs & derivatives
Antipyrine - pharmacokinetics
Autoradiography
Biological and medical sciences
Blood Flow Velocity
Carbon Radioisotopes
Cerebrovascular Circulation
Disease Models, Animal
Disease Progression
Fluorine Radioisotopes
Fluorodeoxyglucose F18 - pharmacokinetics
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Male
Medical sciences
Neostriatum - blood supply
Neostriatum - diagnostic imaging
Neostriatum - physiopathology
Nervous system (semeiology, syndromes)
Neurology
Rats
Rats, Sprague-Dawley
Somatosensory Cortex - blood supply
Somatosensory Cortex - diagnostic imaging
Somatosensory Cortex - physiopathology
Stroke - diagnostic imaging
Stroke - pathology
Stroke - physiopathology
Thalamus - blood supply
Thalamus - diagnostic imaging
Thalamus - physiopathology
Tomography, Emission-Computed
Vascular diseases and vascular malformations of the nervous system
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Summary:Stroke produces diaschisis in adjacent and connected regions. The sequential changes in diaschisis over time and the relationship of regions of diaschisis to functional cortical areas and regions of poststroke neuroplasticity have not been determined. Small cortical strokes were produced in the barrel cortex of rats. Relative glucose metabolism was determined in vivo over time with [18F]fluorodeoxyglucose small-animal positron emission tomography. Cerebral blood flow was measured with [14C]iodoantipyrine. Regions of hypometabolism and hypoperfusion were compared with histological damage in the same animals. Small cortical strokes produce an initial network of hypometabolism in a broad region of cortex adjacent to the stroke and in the striatum and thalamus on day 1. Cerebral blood flow is diminished only immediately around the cortical infarct on day 1. A substantial area of cortex adjacent to the stroke remains hypometabolic on day 8. This persistent cortical hypometabolism occupies the somatosensory cortex, forelimb motor cortex, and second somatosensory area. Focal stroke produces ipsilateral diaschisis in connected cortical regions that is clearly distant from subtotal damage and may play a role in poststroke neuroplasticity.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.str.0000117235.11156.55