Long-term follow-up of laminin alpha2 (merosin)-deficient muscular dystrophy in a cat

Progressive muscle weakness beginning at 6 months of age was observed in a male Persian-mix cat. Muscle atrophy and joint contracture progressed over the next 3 years. The cat had developed gait difficulty at 8 months of age. The cat died at age of 5 years and 3 months due to an acute respiratory di...

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Bibliographic Details
Published in:Journal of feline medicine and surgery 2008-07, Vol.10 (3), p.274-279
Main Authors: Awamura, Yuichi, Uchida, Kazuyuki, Arikawa-Hirasawa, Eri
Format: Article
Language:English
Subjects:
Animals
Cat Diseases - diagnosis
Cat Diseases - genetics
Cats
Contracture - etiology
Contracture - veterinary
Follow-Up Studies
Laminin - deficiency
Muscle Rigidity - veterinary
Muscular Dystrophy, Animal - complications
Muscular Dystrophy, Animal - genetics
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Summary:Progressive muscle weakness beginning at 6 months of age was observed in a male Persian-mix cat. Muscle atrophy and joint contracture progressed over the next 3 years. The cat had developed gait difficulty at 8 months of age. The cat died at age of 5 years and 3 months due to an acute respiratory disorder. The clinical, laboratory, necropsy and histopathological findings of the cat were consistent with those of muscular dystrophy. The cat was diagnosed as having laminin alpha2 (merosin)-deficient muscular dystrophy on the basis of immunohistochemical findings. The cat was born in an inbred colony, and another related cat exhibited similar clinical signs. Few cases of laminin alpha2-deficient muscular dystrophy have been reported in cats, and this report provides additional information about the disease.
ISSN:1098-612X
1532-2750
DOI:10.1016/j.jfms.2007.11.003