Spike-Firing Resonance in Hypoglossal Motoneurons

Department of Physiology and Biophysics, University of Washington, Seattle, Washington Submitted 18 September 2007; accepted in final form 26 March 2008 During an inspiration the output of hypoglossal (XII) motoneurons (HMs) in vitro is characterized by synchronous oscillatory firing in the 20- to 4...

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Bibliographic Details
Published in:Journal of neurophysiology 2008-06, Vol.99 (6), p.2916-2928
Main Authors: van Brederode, Johannes F. M, Berger, Albert J
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Action Potentials - physiology
Animals
Brain Stem - cytology
Dose-Response Relationship, Radiation
Electric Stimulation - methods
Hypoglossal Nerve - drug effects
Hypoglossal Nerve - physiology
In Vitro Techniques
Mice
Motor Neurons - physiology
Motor Neurons - radiation effects
Patch-Clamp Techniques - methods
Recruitment, Neurophysiological - physiology
Recruitment, Neurophysiological - radiation effects
Synaptic Transmission - physiology
Synaptic Transmission - radiation effects
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Summary:Department of Physiology and Biophysics, University of Washington, Seattle, Washington Submitted 18 September 2007; accepted in final form 26 March 2008 During an inspiration the output of hypoglossal (XII) motoneurons (HMs) in vitro is characterized by synchronous oscillatory firing in the 20- to 40-Hz range. To maintain synchronicity it is important that the cells fire with high reliability and precision. It is not known whether the intrinsic properties of HMs are tuned to maintain synchronicity when stimulated with time-varying inputs. We intracellularly recorded from HMs in an in vitro brain stem slice preparation from juvenile mice. Cells were held at or near spike threshold and were stimulated with steady or swept sine-wave current functions (10-s duration; 0- to 40-Hz range). Peristimulus time histograms were constructed from spike times based on threshold crossings. Synaptic transmission was suppressed by including blockers of GABAergic, glycinergic, and glutamatergic neurotransmission in the bath solution. Cells responded to sine-wave stimulation with bursts of action potentials at low (
ISSN:0022-3077
1522-1598
DOI:10.1152/jn.01037.2007