Porous calcium polyphosphate scaffolds for bone substitute applications in vivo studies

Porous rods (6 mm in length and 4 mm in diameter) of calcium polyphosphate (CPP) made by gravity sintering of particles in the size ranges of 45–105, 105–150, and 150–250 μm and with initial volume percent porosity in the range of 35–45% were implanted in the distal femur of New Zealand white rabbit...

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Bibliographic Details
Published in:Biomaterials 2002-05, Vol.23 (9), p.2063-2070
Main Authors: Grynpas, M.D., Pilliar, R.M., Kandel, R.A., Renlund, R., Filiaggi, M., Dumitriu, M.
Format: Article
Language:English
Subjects:
Animals
Bone and Bones - metabolism
Bone ingrowth
Bone Substitutes - chemistry
Bone Substitutes - pharmacology
Calcium Phosphates - chemistry
Calcium Phosphates - pharmacology
Calcium polyphosphate
Femur - anatomy & histology
Femur - metabolism
In vivo degradation
Particle size
Prostheses and Implants
Rabbit model
Rabbits
Time Factors
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Summary:Porous rods (6 mm in length and 4 mm in diameter) of calcium polyphosphate (CPP) made by gravity sintering of particles in the size ranges of 45–105, 105–150, and 150–250 μm and with initial volume percent porosity in the range of 35–45% were implanted in the distal femur of New Zealand white rabbits. In an initial experiment, four rabbits implanted with rods made from coarse particles (150–250 μm) were sacrificed at each of the following time points: 2 days, 2 weeks, 6 weeks and 12 weeks. In a subsequent experiment, 10 rabbits were implanted with rods made by sintering 45–105 μm particles and another 10 were made by using particles of 105–150 μm. These rabbits were sacrificed at 6 weeks (five rabbits) and 1 year (five rabbits). No adverse reaction was found histologically at any time point in either experiment. These experiments show that CPP macroporous rods can support bone ingrowth and that between 12 weeks and 1 year, the amount of bones formed is equivalent to the natural bone volume found at similar sites. The degradation of the CPP material is inversely proportional to the original particle size and is rapid initially (within the first 6 weeks) and slows down thereafter. In conclusion, this material seems to promote rapid bone ingrowth and can be tailored to degrade at a given rate in vivo to some degree through appropriate selection of the starting particle size.
ISSN:0142-9612
1878-5905
DOI:10.1016/S0142-9612(01)00336-2