A Sequence-Based Map of the Nine Genes of the Human Interleukin-1 Cluster

Six novel genes encoding proteins with the interleukin (IL)-1 fold have been identified recently. The classical family members are involved in inflammatory signaling. Previous work has placed the novel genes close to or within the same cluster as IL1A, IL1B, and IL1RN, which occupy an ∼400-kb interv...

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Bibliographic Details
Published in:	Genomics (San Diego, Calif.) Calif.), 2002-05, Vol.79 (5), p.718-725
Main Authors:	Nicklin, Martin J.H, Barton, Jenny L, Nguyen, Minh, FitzGerald, Michael G, Duff, Gordon W, Kornman, Ken
Format:	Article
Language:	eng
Subjects:	Amino Acid Sequence Biological and medical sciences chromosome 2 Chromosome Mapping - methods Chromosomes, Human, Pair 2 - genetics CpG Islands - genetics Fundamental and applied biological sciences. Psychology Gene Order Genes. Genome Humans IL1A gene IL1B gene IL1F8 gene IL1RN gene Interleukin-1 - genetics Molecular and cellular biology Molecular genetics Molecular Sequence Data Multigene Family - genetics Phylogeny Polymorphism, Genetic Sequence Homology, Amino Acid
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Summary:	Six novel genes encoding proteins with the interleukin (IL)-1 fold have been identified recently. The classical family members are involved in inflammatory signaling. Previous work has placed the novel genes close to or within the same cluster as IL1A, IL1B, and IL1RN, which occupy an ∼400-kb interval on chromosome 2. We have combined the incomplete public database sequence with our own sequence to generate a reference sequence and map that encompass all of the novel genes, allowing determination of the gene structures, precise localization of exons, and determination of distances between conventional SNP and microsatellite markers. Gene order from centromere to telomere is IL1A-IL1B-IL1F7-IL1F9-IL1F6-IL1F8-IL1F5-IL1F10-IL1RN, of which only IL1A, IL1B, and IL1F8 are transcribed towards the centromere. The gene order relates to the volutionary relationship between the genes. Key features of exon boundaries are conserved. There is no evidence for other IL-1 family members within the cluster.
ISSN:	0888-7543 1089-8646