Plasma amino acids in cirrhosis and after liver transplantation: influence of liver function, hepatic hemodynamics and circulating hormones

Liver cirrhosis is characterized by substantial changes in amino acid (AA) metabolism, resulting in a deranged plasma AA profile. To investigate the effect of liver transplantation (OLT), we studied arterial AA profiles in 52 patients with advanced cirrhosis, 16 stable patients over 6 months after O...

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Bibliographic Details
Published in:Clinical transplantation 2002-02, Vol.16 (1), p.9-17
Main Authors: Tietge, Uwe JF, Bahr, Matthias J, Manns, Michael P, Böker, Klaus HW
Format: Article
Language:English
Subjects:
Adult
amino acids
Amino Acids - blood
Analysis of Variance
Biological and medical sciences
Case-Control Studies
cirrhosis
Female
Hemodynamics
Hormones - blood
Humans
HVPG
Liver Cirrhosis - blood
Liver Cirrhosis - surgery
Liver Transplantation
Liver, biliary tract, pancreas, portal circulation, spleen
Male
Medical sciences
metabolism
Middle Aged
Radioimmunoassay
Splanchnic Circulation
Statistics, Nonparametric
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
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Summary:Liver cirrhosis is characterized by substantial changes in amino acid (AA) metabolism, resulting in a deranged plasma AA profile. To investigate the effect of liver transplantation (OLT), we studied arterial AA profiles in 52 patients with advanced cirrhosis, 16 stable patients over 6 months after OLT and 48 controls. Changes in AA levels were correlated with portal pressure (hepatic venous pressure gradient), functional hepatic blood flow (indocyanine green extraction) and circulating hormone levels (catecholamines, insulin, C‐peptide). Fourteen of 18 measured AA were significantly altered in cirrhosis and 11 of 18 remained abnormal after OLT compared with controls. Aromatic AA (AAA) and methionine were elevated in cirrhosis (p
ISSN:0902-0063
1399-0012
DOI:10.1034/j.1399-0012.2002.160101.x