Cytokine Signaling in 2002: New Surprises in the Jak/Stat Pathway

The importance of Jak-Stat pathway signaling in regulating cytokine-dependent gene expression and cellular development/survival is well established. Nevertheless, advances continue to be made in defining Jak-Stat pathway effects on different cellular processes and in different organisms. This review...

Full description

Saved in:
Bibliographic Details
Published in:Cell 2002-04, Vol.109 (2), p.S121-S131
Main Authors: O'Shea, John J, Gadina, Massimo, Schreiber, Robert D
Format: Article
Language:English
Subjects:
Animals
Carrier Proteins - metabolism
Cytokines - metabolism
DNA-Binding Proteins - chemistry
DNA-Binding Proteins - metabolism
Gene Expression Regulation
Humans
Intracellular Signaling Peptides and Proteins
Janus Kinase 1
Methylation
Protein Inhibitors of Activated STAT
Protein-Tyrosine Kinases - metabolism
Proteins - metabolism
Receptors, Cytokine - metabolism
Repressor Proteins
Signal Transduction
STAT1 Transcription Factor
Suppressor of Cytokine Signaling 1 Protein
Suppressor of Cytokine Signaling Proteins
Trans-Activators - chemistry
Trans-Activators - metabolism
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The importance of Jak-Stat pathway signaling in regulating cytokine-dependent gene expression and cellular development/survival is well established. Nevertheless, advances continue to be made in defining Jak-Stat pathway effects on different cellular processes and in different organisms. This review focuses on recent advances in the field and highlights some of the most active areas of Jak-Stat pathway research.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(02)00701-8