Metabolites from the endophytic fungus Xylaria sp. PSU-D14

Glucoside derivatives, xylarosides A ( 1) and B ( 2), were isolated from the broth extract of the endophytic fungus Xylaria sp. PSU-D14 together with two known compounds. The structures were assigned by spectroscopic methods. Sordaricin ( 3), one of the known metabolites, exhibited antifungal activi...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 2008-06, Vol.69 (9), p.1900-1902
Main Authors: Pongcharoen, Wipapan, Rukachaisirikul, Vatcharin, Phongpaichit, Souwalak, Kühn, Till, Pelzing, Matthias, Sakayaroj, Jariya, Taylor, Walter C.
Format: Article
Language:English
Subjects:
Ascomycota
Benzopyranones
Biological and medical sciences
Candida albicans
Chemical constitution
chemical structure
endophytes
Fundamental and applied biological sciences. Psychology
Garcinia dulcis
Glucosides
Glucosides - chemistry
Glucosides - metabolism
human health
Magnetic Resonance Spectroscopy
medicinal properties
Microbiology
Molecular Structure
Morphology, structure, chemical composition
Mycology
Plant physiology and development
Sordaricin
spectral analysis
Xylaria
Xylaria sp
Xylariales - chemistry
Xylariales - classification
Xylariales - metabolism
xylarosides
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Summary:Glucoside derivatives, xylarosides A ( 1) and B ( 2), were isolated from the broth extract of the endophytic fungus Xylaria sp. PSU-D14 together with two known compounds. The structures were assigned by spectroscopic methods. Sordaricin ( 3), one of the known metabolites, exhibited antifungal activity against Candida albicans ATCC90028 with a MIC value of 32 μg/ml. Glucoside derivatives, xylarosides A ( 1) and B ( 2), were isolated from the broth extract of the endophytic fungus Xylaria sp. PSU-D14 along with two known compounds, sordaricin ( 3) and 2,3-dihydro-5-hydroxy-2-methyl-4 H-1-benzopyran-4-one ( 4). The structures were assigned by spectroscopic methods. Sordaricin ( 3), one of the known metabolites, exhibited moderate antifungal activity against Candida albicans ATCC90028 with a MIC value of 32 μg/ml.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2008.04.003