Bcl-2 associated athanogene-1 overexpression in diffuse large B-cell lymphoma

Apoptosis and cell cycle regulation play an important role in pathogenesis and tumor progression in patients with Diffuse Large B-Cell Lymphoma (DLBCL). Bcl-2 associated athanogene-1 (BAG-1) is an antiapoptotic protein as well as a regulator of cell growth. There is no conclusive evidence about BAG-...

Full description

Saved in:
Bibliographic Details
Published in:Iranian journal of immunology 2008-06, Vol.5 (2), p.124-130
Main Authors: Ataollahi, Mohammadreza, Salehi, Mansour, Doostan, Iman, Kabiri, Zahra, Mohajeri, Mohammadreza, Mahmoodi, Farzaneh, Shokouhi, Raheleh, Javan, Shadi, Meshkibaf, Mohammad Hassan, Miladpoor, Behnoosh
Format: Article
Language:English
Subjects:
DNA-Binding Proteins - metabolism
Humans
Immunohistochemistry
Lymph Nodes - metabolism
Lymphoma, Large B-Cell, Diffuse - metabolism
Lymphoma, Large B-Cell, Diffuse - pathology
Transcription Factors - metabolism
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Apoptosis and cell cycle regulation play an important role in pathogenesis and tumor progression in patients with Diffuse Large B-Cell Lymphoma (DLBCL). Bcl-2 associated athanogene-1 (BAG-1) is an antiapoptotic protein as well as a regulator of cell growth. There is no conclusive evidence about BAG-1 protein expression in this disease. To investigate the expression level of BAG-1 protein in DLBCL. Thirty patients diagnosed from 1997-2004, as having DLBCL, were selected. Also 30 normal lymph nodes were included as normal counterparts in this study. BAG-1 expression was determined by immunohistochemical staining in both DLBCL and normal lymph node samples. Of the 30 DLBCLs examined, 100% were positive for nuclear and 83% were positive for cytoplasmic BAG-1 staining. Of the 30 normal lymph nodes investigated, 20% were positive for nuclear and 0% were positive for cytoplasmic BAG-1 staining. Nuclear staining in DLBCL samples was significantly higher than those of normal lymph nodes (100% versus 20%, p
ISSN:1735-1383
1735-367X