Coordinate regulation of gallbladder motor function in the gut‐liver axis

Gallstones are one of the most common digestive diseases with an estimated prevalence of 10%‐15% in adults living in the western world, where cholesterol‐enriched gallstones represent 75%‐80% of all gallstones. In cholesterol gallstone disease, the gallbladder becomes the target organ of a complex m...

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Published in:Hepatology (Baltimore, Md.) Md.), 2008-06, Vol.47 (6), p.2112-2126
Main Authors: Portincasa, Piero, Di Ciaula, Agostino, Wang, Helen H., Palasciano, Giuseppe, van Erpecum, Karel J., Moschetta, Antonio, Wang, David Q.‐H.
Format: Article
Language:English
Subjects:
Bile - physiology
Biological and medical sciences
Gallbladder - physiology
Gallbladder - physiopathology
Gallstones - etiology
Gallstones - physiopathology
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal Motility - physiology
Gastrointestinal Tract - physiology
Humans
Liver - physiology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
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Summary:Gallstones are one of the most common digestive diseases with an estimated prevalence of 10%‐15% in adults living in the western world, where cholesterol‐enriched gallstones represent 75%‐80% of all gallstones. In cholesterol gallstone disease, the gallbladder becomes the target organ of a complex metabolic disease. Indeed, a fine coordinated hepatobiliary and gastrointestinal function, including gallbladder motility in the fasting and postprandial state, is of crucial importance to prevent crystallization and precipitation of excess cholesterol in gallbladder bile. Also, gallbladder itself plays a physiopathological role in biliary lipid absorption. Here, we present a comprehensive view on the regulation of gallbladder motor function by focusing on recent discoveries in animal and human studies, and we discuss the role of the gallbladder in the pathogenesis of gallstone formation. (HEPATOLOGY 2008;47:2112–2126.)
ISSN:0270-9139
1527-3350
DOI:10.1002/hep.22204