Neuregulins and Cancer

The neuregulins represent the largest subclass of polypeptide factors of the epidermal growth factor family of ligands. These molecules are synthesized as membrane-bound, biologically active growth factors that act by binding to the HER/ErbB receptor tyrosine kinases. Preclinical data have indicated...

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Bibliographic Details
Published in:Clinical cancer research 2008-06, Vol.14 (11), p.3237-3241
Main Authors: MONTERO, Juan Carlos, RODRIGUEZ-BARRUECO, Ruth, OCANA, Alberto, DIAZ-RODRIGUEZ, Elena, ESPARIS-OGANDO, Azucena, PANDIELLA, Atanasio
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Biological and medical sciences
Cell Transformation, Neoplastic - metabolism
HER receptors
Humans
Medical sciences
Neoplasms - metabolism
Neuregulin
Neuregulins - metabolism
Pharmacology. Drug treatments
targeted therapies
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Summary:The neuregulins represent the largest subclass of polypeptide factors of the epidermal growth factor family of ligands. These molecules are synthesized as membrane-bound, biologically active growth factors that act by binding to the HER/ErbB receptor tyrosine kinases. Preclinical data have indicated that increased expression and function of neuregulins may provoke cancer. Furthermore, neuregulin expression has been detected in several neoplasias, and their presence may correlate with response to treatments that target the HER receptors such as trastuzumab. In addition, the neuregulins have also been implicated in resistance to anti-HER therapies. Therefore, targeting of the neuregulins may be helpful in neoplastic diseases in which these polypeptide factors contribute to tumor generation and/or maintenance.
ISSN:1078-0432
1557-3265
DOI:10.1158/1078-0432.CCR-07-5133