MR factor analysis: Improved technology for the assessment of 2D dynamic structures of benign and malignant salivary gland tumors

Purpose To establish an MR factor analysis technique for two‐dimensional (2D) MR dynamic structures of benign and malignant salivary gland tumors. Materials and Methods Dynamic contrast‐enhanced MRI using a surface coil was performed on 36 patients with benign (N = 24) or malignant (N = 12) salivary...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2008-06, Vol.27 (6), p.1256-1262
Main Authors: Eida, Sato, Ohki, Masafumi, Sumi, Misa, Yamada, Toshiro, Nakamura, Takashi
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnosis
Aged
Cohort Studies
Contrast Media - administration & dosage
contrast medium
Diagnosis, Differential
dynamic study
factor analysis
Factor Analysis, Statistical
Feasibility Studies
Female
Gadolinium DTPA
histology
Humans
Image Enhancement - methods
Image Processing, Computer-Assisted - methods
Lymphoma - diagnosis
Magnetic Resonance Imaging - methods
Male
Middle Aged
MR imaging
Neoplasms, Complex and Mixed - diagnosis
Salivary Gland Neoplasms - diagnosis
salivary gland tumor
Salivary Glands - pathology
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Summary:Purpose To establish an MR factor analysis technique for two‐dimensional (2D) MR dynamic structures of benign and malignant salivary gland tumors. Materials and Methods Dynamic contrast‐enhanced MRI using a surface coil was performed on 36 patients with benign (N = 24) or malignant (N = 12) salivary gland tumors. Signal intensity kinetics in each pixel of the tumors after contrast medium injections were semiautomatically categorized into four patterns (slow uptake, rapid uptake with high washout, rapid uptake with low washout, and flat). The 2D distributions of the kinetic patterns in the tumors were compared with the histological features of the corresponding parts of the excised tumors and with overall kinetics obtained by a conventional analysis. Results The MR factor analysis technique allowed the pixel‐to‐pixel evaluation of the contrast enhancement kinetics of the salivary gland tumors. The 2D distributions of the time‐intensity curve (TIC) patterns correlated well with the histological features of the salivary gland tumors and allowed more detailed dynamic structures of the tumors compared with the results obtained by the conventional dynamic study analysis. Conclusion The proposed MR factor analysis would be clinically feasible to diagnose salivary gland tumors and tumor‐like lesions. J. Magn. Reson. Imaging 2008;27:1256–1262. © 2008 Wiley‐Liss, Inc.
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.21349