Circulating nitric oxide is modulated by recombinant human TSH administration during monitoring of thyroid cancer remnant

During the administration of recombinant human TSH (rhTSH) to monitor differentiated thyroid carcinoma, mild side effects, such as nausea and headaches, often occur. The origin of these is not clear. Since changes in TSH and thyroid hormones can modulate some endothelial-derived factors, we aimed at...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2003-12, Vol.26 (12), p.1192-1197
Main Authors: GIUSTI, M, VALENTI, S, GUAZZINI, B, MOLINARI, E, CAVALLERO, D, AUGERI, C, MINUTO, F
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Carcinoma, Papillary - blood
Carcinoma, Papillary - diagnosis
Carcinoma, Papillary - surgery
Endocrinopathies
Female
Fundamental and applied biological sciences. Psychology
Humans
Male
Medical sciences
Middle Aged
Neoplasm, Residual - blood
Neoplasm, Residual - diagnosis
Nitrates - blood
Nitrites - blood
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Population Surveillance
Recombinant Proteins
Thyroid Neoplasms - blood
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - surgery
Thyroid. Thyroid axis (diseases)
Thyroidectomy
Thyrotropin
Vertebrates: endocrinology
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Summary:During the administration of recombinant human TSH (rhTSH) to monitor differentiated thyroid carcinoma, mild side effects, such as nausea and headaches, often occur. The origin of these is not clear. Since changes in TSH and thyroid hormones can modulate some endothelial-derived factors, we aimed at testing whether rhTSH administration induces changes in nitric oxide. We studied 25 patients (56.6+/-12.6 yr) who had undergone thyroidectomy followed by ablative radioiodine for papillary thyroid cancer and who were under follow-up. While L-thyroxine therapy continued, thyroglobulin (Tg), TSH, free-T3, free-T4 and nitrite-plus-nitrate (NOx) concentrations were evaluated before and after rhTSH administration (0.9 mg i.m. on 2 consecutive days). Mean TSH showed a huge increase from baseline (0.1+/-0.0 mIU/l) to day 3 (216.3+/-17.5 mIU/l, p
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03349156