R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population

Stone et al. previously reported an association between the TBC1D1 gene variant R125W (rs35859249) and severe obesity in women from US pedigrees. We attempted to replicate this result in 9714 French Caucasian individuals, combining family-based and general population studies. We confirmed an associa...

Full description

Saved in:
Bibliographic Details
Published in:Human molecular genetics 2008-06, Vol.17 (12), p.1798-1802
Main Authors: Meyre, David, Farge, Morgane, Lecoeur, Cécile, Proenca, Christine, Durand, Emmanuelle, Allegaert, Frédéric, Tichet, Jean, Marre, Michel, Balkau, Beverley, Weill, Jacques, Delplanque, Jérôme, Froguel, Philippe
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Child
Chromosomes, Human, Pair 4
Classical genetics, quantitative genetics, hybrids
European Continental Ancestry Group - genetics
Female
France
Fundamental and applied biological sciences. Psychology
Genetic Predisposition to Disease
Genetics of eukaryotes. Biological and molecular evolution
GTPase-Activating Proteins - genetics
Humans
Male
Medical sciences
Metabolic diseases
Methods, theories and miscellaneous
Microsatellite Repeats
Middle Aged
Molecular and cellular biology
Obesity
Obesity - genetics
Pedigree
Polymorphism, Single Nucleotide
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Stone et al. previously reported an association between the TBC1D1 gene variant R125W (rs35859249) and severe obesity in women from US pedigrees. We attempted to replicate this result in 9714 French Caucasian individuals, combining family-based and general population studies. We confirmed an association with familial obesity (defined as body mass index (BMI) ≥ 97th percentile) in women from 1109 obesity-selected pedigrees (Z-score = 2.70, P = 0.008). Analysis of 16 microsatellite markers on chromosome 4 restricted to the 42 pedigrees carrying the TBC1D1 R125W variant allele also revealed a suggestive evidence of linkage with obesity (maximum likelihood binomial LOD of 2.73, P = 0.0002) on chromosome 4p14, where resides TBC1D1. In contrast, R125W variant was neither associated with BMI nor with obesity in a large population-based cohort. These results confirm a putative role of TBC1D1 R125W variant in familial obesity predisposition.
ISSN:0964-6906
1460-2083
DOI:10.1093/hmg/ddn070