Congenital hyposomatotropism in a domestic shorthair cat presenting with congenital corneal oedema

A six-month-old, female, domestic shorthair cat was presented with a history of failure to grow and bilateral corneal opacity caused by corneal oedema. Congenital hyposomatotropism and possible secondary hypothyroidism were diagnosed on the basis of fasting serum levels of insulin-like growth factor...

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Bibliographic Details
Published in:Journal of small animal practice 2008-06, Vol.49 (6), p.306-309
Main Authors: Donaldson, D, Billson, F.M, Scase, T.J, Sparkes, A.H, McConnell, F, Mould, J.R.B, Adams, V
Format: Article
Language:English
Subjects:
Animals
blood serum
breeds
cat diseases
Cat Diseases - congenital
Cat Diseases - diagnosis
Cats
complications
congenital abnormalities
cornea
corneal diseases
Corneal Edema - congenital
Corneal Edema - etiology
Corneal Edema - pathology
Corneal Edema - veterinary
disease diagnosis
Domestic Shorthair (cat breed)
Dwarfism, Pituitary - complications
Dwarfism, Pituitary - congenital
Dwarfism, Pituitary - veterinary
edema
endothelial cells
epithelial cells
Female
histopathology
hormone secretion
hyposomatotropism
hypothyroidism
Immunohistochemistry - veterinary
insulin-like growth factor I
Insulin-Like Growth Factor I - metabolism
somatotropin
thyroxine
Thyroxine - blood
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Summary:A six-month-old, female, domestic shorthair cat was presented with a history of failure to grow and bilateral corneal opacity caused by corneal oedema. Congenital hyposomatotropism and possible secondary hypothyroidism were diagnosed on the basis of fasting serum levels of insulin-like growth factor-1 and thyroxine levels, respectively. These endocrinopathies are rare in the cat and have not been reported to cause ocular signs. The cat died during investigation of these diseases, and histopathological examination of the eyes showed significantly reduced corneal endothelial cell density and number of corneal epithelial cell layers when compared with age-matched healthy control corneas. These changes were implicated in the development of the corneal oedema.
ISSN:0022-4510
1748-5827
DOI:10.1111/j.1748-5827.2007.00517.x