Stereoselective Synthesis of myo-Inositol via Ring-Closing Metathesis:  A Building Block for Glycosylphosphatidylinositol (GPI) Anchor Synthesis

Here we report a concise stereoselective synthesis of myo-inositol via ring-closing metathesis. A readily available bis-Weinreb amide of d-tartrate served as a key intermediate.

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Bibliographic Details
Published in:Organic letters 2002-04, Vol.4 (8), p.1359-1361
Main Authors: Conrad, Rosemary M, Grogan, Michael J, Bertozzi, Carolyn R
Format: Article
Language:English
Subjects:
Animals
Carbohydrate Sequence
Erythrocytes - enzymology
Glycosylphosphatidylinositols - chemical synthesis
Indicators and Reagents
Inositol - chemical synthesis
Inositol - chemistry
Stereoisomerism
Trypanosoma brucei brucei - chemistry
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Description
Summary:Here we report a concise stereoselective synthesis of myo-inositol via ring-closing metathesis. A readily available bis-Weinreb amide of d-tartrate served as a key intermediate.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol025680k