Selective progesterone receptor modulators (SPRMs): a novel therapeutic concept in endometriosis

Endometriosis, the presence of endometrial tissue outside the uterus, is a progressive, estrogen-dependent disease and occurs nearly exclusively in menstruating women of reproductive age. Pain syndrome, however, represents the major clinical problem of this disease, manifested as dysmenorrhea, pelvi...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2002-03, Vol.955 (1), p.373-388
Main Authors: Chwalisz, Kristof, Garg, Ramesh, Brenner, Robert M, Schubert, Gerd, Elger, Walter
Format: Article
Language:English
Subjects:
Animals
Endometriosis - drug therapy
Endometriosis - metabolism
Female
Hormone Antagonists - pharmacology
Hormone Antagonists - therapeutic use
Humans
Ovulation - drug effects
Pregnancy
Prostaglandins - metabolism
Receptors, Progesterone - antagonists & inhibitors
Receptors, Progesterone - metabolism
Uterus - drug effects
Uterus - metabolism
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Summary:Endometriosis, the presence of endometrial tissue outside the uterus, is a progressive, estrogen-dependent disease and occurs nearly exclusively in menstruating women of reproductive age. Pain syndrome, however, represents the major clinical problem of this disease, manifested as dysmenorrhea, pelvic pain, lower abdominal pain, and dyspareunia. The manifestation of the disease, that is, the pain syndrome, rather than the disease itself currently represents the major indication for both the medical and surgical therapies of endometriosis. The major drawbacks of current medical therapies of endometriosis are sometimes severe side effects. In this review, selective progesterone receptor modulators (SPRMs, mesoprogestins) as a potential therapeutic concept in endometriosis are discussed. Due to endometrial selectivity and favorable pharmacological profile, SPRMs may have advantages over the current medical treatments of this disease. Other emerging therapeutic approaches for this disease are also mentioned.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2002.tb02798.x