Sweat conductivity and chloride titration for cystic fibrosis diagnosis in 3834 subjects

Sweat test is the standard for cystic fibrosis (CF) diagnosis. Conductivity is an alternative method not yet approved, in spite of its good correlation with chloride concentration. The aim was to assess the capacity of sweat conductivity to discriminate between CF and non-CF subjects. Automated meas...

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Bibliographic Details
Published in:Journal of cystic fibrosis 2003-03, Vol.2 (1), p.1-7
Main Authors: Lezana, José Luis, Vargas, Mario H., Karam-Bechara, José, Aldana, Ruth S., Furuya, María E.Y.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Child, Preschool
Chloride titration
Chlorides - analysis
Conductivity
Cystic fibrosis
Cystic Fibrosis - diagnosis
Electric Conductivity
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
ROC Curve
Sweat - chemistry
Sweat - physiology
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Summary:Sweat test is the standard for cystic fibrosis (CF) diagnosis. Conductivity is an alternative method not yet approved, in spite of its good correlation with chloride concentration. The aim was to assess the capacity of sweat conductivity to discriminate between CF and non-CF subjects. Automated measurements of conductivity and chloride concentration were carried out on the same sweat samples from subjects with clinical suspicion of CF. Sweat samples from 3834 subjects, median age 1.8 years (range 1 month–54 years) were analysed, and those with chloride titration >60 mmol/l were considered as CF patients (n=294). Conductivity median values in CF and non-CF subjects were 111 mmol/l (82–148) and 36 mmol/l (12–89), respectively. The Spearman correlation between chloride titration and conductivity was r=0.60 (P
ISSN:1569-1993
1873-5010
DOI:10.1016/S1569-1993(02)00146-7