Microarray Analysis of Interferon-regulated Genes in SLE

Altered regulation of interferon- (IFN ) in systemic lupus erythematosus (SLE) was first demonstrated nearly 25 years ago. However, only recently has due attention been directed towards the central role of this cytokine family in SLE. Several laboratories have used large-scale microarray technology...

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Bibliographic Details
Published in:Autoimmunity (Chur, Switzerland) Switzerland), 2003-12, Vol.36 (8), p.481-490
Main Authors: Crow, Mary K., Kirou, Kyriakos A., Wohlgemuth, Jay
Format: Article
Language:English
Subjects:
Cytotoxicity, Immunologic - physiology
Gene expression
Gene Expression Profiling - methods
Gene Expression Regulation
Humans
Interferon Type I - immunology
Interferon Type I - metabolism
Interferon-alpha - biosynthesis
Interferon-alpha - immunology
Interferon-alpha - metabolism
Interferon-induced genes
Interferons
Leukocytes, Mononuclear - immunology
Leukocytes, Mononuclear - metabolism
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - physiopathology
Microarray
Oligonucleotide Array Sequence Analysis
Systemic lupus erythematosus
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Summary:Altered regulation of interferon- (IFN ) in systemic lupus erythematosus (SLE) was first demonstrated nearly 25 years ago. However, only recently has due attention been directed towards the central role of this cytokine family in SLE. Several laboratories have used large-scale microarray technology to study global gene expression patterns in heterogeneous populations of peripheral blood cells from lupus patients and control subjects. The results of these studies demonstrate that IFN-regulated genes are among the most significantly overexpressed in SLE mononuclear cells. In view of the protean effects of IFNs on immune system function, increased activity of IFNs may account for many of the immune system alterations that characterize SLE and contribute to autoimmunity. Definition of the nature of the major IFNs, or other factors, that drive the IFN-regulated gene expression signature noted in SLE is an important area for investigation that may lead to new approaches to targeted therapy of SLE.
ISSN:0891-6934
1607-842X
DOI:10.1080/08916930310001625952