H2S generated by heart in rat and its effects on cardiac function

Hydrogen sulfide (H2S), which was considered as a novel gasotransmitter, is produced endogenously from L-cysteine in mammalian brain and vessels, and might be a physiological function regulator to these organs. Here, we showed that mRNA for H2S producing enzyme, cystathionine gamma-lyase, was expres...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2004-01, Vol.313 (2), p.362-368
Main Authors: Geng, Bin, Yang, Jinghui, Qi, Yongfen, Zhao, Jing, Pang, Yongzheng, Du, Junbao, Tang, Chaoshu
Format: Article
Language:English
Subjects:
Animals
Aorta - metabolism
Blood Pressure
Brain - metabolism
Cystathionine gamma-Lyase - biosynthesis
Dose-Response Relationship, Drug
Glyburide - pharmacology
Heart - physiology
Heart Rate
Hydrogen Sulfide - metabolism
Hydrogen Sulfide - pharmacology
Male
Myocardium - enzymology
Myocardium - metabolism
Rats
Rats, Wistar
RNA, Messenger - biosynthesis
Sulfides - antagonists & inhibitors
Sulfides - pharmacology
Ventricular Pressure
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Summary:Hydrogen sulfide (H2S), which was considered as a novel gasotransmitter, is produced endogenously from L-cysteine in mammalian brain and vessels, and might be a physiological function regulator to these organs. Here, we showed that mRNA for H2S producing enzyme, cystathionine gamma-lyase, was expressed in myocardial tissues and H2S could endogenously be produced in myocardial tissues. Negative inotropic effect of H2S was proved in present study in vitro and in vivo experiments, and the effect could partly be blocked by glibenclamide, a KATP channel blocker. An intravenous bolus injection of NaHS provoked a decrease in central venous pressure. The present findings suggested that H2S could be endogenously produced by heart tissues, as a physiological cardiac function regulator, mediated by KATP channel pathway.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2003.11.130