Association of Vitamin A and Zinc Status with Altered Intestinal Permeability: Analyses of Cohort Data from Northeastern Brazil

To examine the association of intestinal barrier function with vitamin A deficiency and whether supplementation of micronutrients improves intestinal function and/or linear growth, height-for-age z-score (HAZ), concentrations of serum retinol and zinc, and intestinal permeability were determined in...

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Bibliographic Details
Published in:Journal of health, population and nutrition population and nutrition, 2003-12, Vol.21 (4), p.309-315
Main Authors: Chen, Ping, Soares, Alberto Melo, Lima, Aldo A.M., Gamble, Mary V., Schorling, John B., Conway, Mark, Barrett, Leah J., Blaner, William S., Guerrant, Richard L.
Format: Article
Language:English
Subjects:
Brazil - epidemiology
Capillary Permeability - drug effects
Child growth
Child nutrition
Child nutrition disorders
Child Nutritional Physiological Phenomena - physiology
Child, Preschool
Children
Children & youth
Cohort Studies
Diarrhea
Diarrhea, Infantile - drug therapy
Female
Growth - drug effects
Health aspects
Humans
Infant
Infant, Newborn
Infectious diseases
Intestinal Absorption - drug effects
Intestinal Absorption - physiology
Lactulose - urine
Large intestine
Liquid chromatography
Male
Malnutrition
Mannitol - urine
Physiological aspects
Surface areas
Urine
Vitamin A
Vitamin A - administration & dosage
Vitamin A - blood
Vitamin A - physiology
Vitamin A Deficiency
Vitamin deficiency
Zinc
Zinc - administration & dosage
Zinc - blood
Zinc - deficiency
Zinc - physiology
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Summary:To examine the association of intestinal barrier function with vitamin A deficiency and whether supplementation of micronutrients improves intestinal function and/or linear growth, height-for-age z-score (HAZ), concentrations of serum retinol and zinc, and intestinal permeability were determined in a cross-sectional sample of 75 children in northeastern Brazil. Effects of vitamin A and supplementation of zinc on intestinal permeability and growth were also determined comparing results before and after treatment in 20 children and age-matched controls. Lactulose:mannitol (L/M) permeability ratios inversely correlated with serum retinol concentrations (r=-0.55, p
ISSN:1606-0997
2072-1315