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Transcription of the M1 muscarinic receptor gene in neurons and neuronal progenitors of the embryonic rat forebrain
Development of the nervous system is accompanied by expansion and differentiation of the neuronal progenitors within the embryonic neuroepithelium. Although the role of growth factors in this process is well documented, there is increasing evidence for a role of neurotransmitters. Acetylcholine is k...
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| Published in: | Journal of neurochemistry 2004-01, Vol.88 (1), p.70-77 |
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| Language: | English |
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| container_end_page | 77 |
| container_issue | 1 |
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| container_title | Journal of neurochemistry |
| container_volume | 88 |
| creator | Williams, Brenda P. Milligan, Carol J. Street, Miyoko |
| description | Development of the nervous system is accompanied by expansion and differentiation of the neuronal progenitors within the embryonic neuroepithelium. Although the role of growth factors in this process is well documented, there is increasing evidence for a role of neurotransmitters. Acetylcholine is known to exert many actions on developing neural cells, but its potential role in neurogenesis is unclear. Here, we show that the M1 muscarinic acetylcholine receptor is expressed in the neuroepithelium of the rat forebrain, where it is found on both nestin+ progenitor cells and TuJ1+ newly differentiated neurons. Furthermore, transcription is governed, at least in part, by regulatory cis elements that are also responsible for driving transcription in neuroblastoma cells. This represents the first demonstration of M1 receptors on neuronal progenitor cells and supports the notion that M1 muscarinic receptors may play a role in development of the nervous system prior to the onset of synaptogenesis and their subsequent role in neurotransmission. |
| doi_str_mv | 10.1111/j.1471-4159.2004.02117.x |
| format | article |
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Psychology ; Genes, Reporter ; muscarinic receptor ; neural stem cells ; neuronal progenitor cells ; Neurons - cytology ; Neurons - metabolism ; Prosencephalon - cytology ; Prosencephalon - embryology ; Prosencephalon - metabolism ; Rats ; Rats, Sprague-Dawley ; Receptor, Muscarinic M1 - biosynthesis ; Receptor, Muscarinic M1 - genetics ; Regulatory Sequences, Nucleic Acid - physiology ; Stem Cells - cytology ; Stem Cells - metabolism ; Transcription, Genetic ; Vertebrates: nervous system and sense organs</subject><ispartof>Journal of neurochemistry, 2004-01, Vol.88 (1), p.70-77</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3917-d10020b9da4405238d5f2b8086148f6ab7527ae3e02e256b45aa17cae0318fc13</citedby><cites>FETCH-LOGICAL-c3917-d10020b9da4405238d5f2b8086148f6ab7527ae3e02e256b45aa17cae0318fc13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-4159.2004.02117.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-4159.2004.02117.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,4043,27956,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15419056$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14675151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williams, Brenda P.</creatorcontrib><creatorcontrib>Milligan, Carol J.</creatorcontrib><creatorcontrib>Street, Miyoko</creatorcontrib><title>Transcription of the M1 muscarinic receptor gene in neurons and neuronal progenitors of the embryonic rat forebrain</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>Development of the nervous system is accompanied by expansion and differentiation of the neuronal progenitors within the embryonic neuroepithelium. Although the role of growth factors in this process is well documented, there is increasing evidence for a role of neurotransmitters. Acetylcholine is known to exert many actions on developing neural cells, but its potential role in neurogenesis is unclear. Here, we show that the M1 muscarinic acetylcholine receptor is expressed in the neuroepithelium of the rat forebrain, where it is found on both nestin+ progenitor cells and TuJ1+ newly differentiated neurons. Furthermore, transcription is governed, at least in part, by regulatory cis elements that are also responsible for driving transcription in neuroblastoma cells. This represents the first demonstration of M1 receptors on neuronal progenitor cells and supports the notion that M1 muscarinic receptors may play a role in development of the nervous system prior to the onset of synaptogenesis and their subsequent role in neurotransmission.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Differentiation - physiology</subject><subject>Cells, Cultured</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Epithelial Cells - cytology</subject><subject>Epithelial Cells - metabolism</subject><subject>Exons</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, Reporter</subject><subject>muscarinic receptor</subject><subject>neural stem cells</subject><subject>neuronal progenitor cells</subject><subject>Neurons - cytology</subject><subject>Neurons - metabolism</subject><subject>Prosencephalon - cytology</subject><subject>Prosencephalon - embryology</subject><subject>Prosencephalon - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptor, Muscarinic M1 - biosynthesis</subject><subject>Receptor, Muscarinic M1 - genetics</subject><subject>Regulatory Sequences, Nucleic Acid - physiology</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - metabolism</subject><subject>Transcription, Genetic</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqNkU1v1DAQhi0EokvhLyBf4JYw49j5OHBAKz5aFbiUs-U4E_AqcRY7Ed1_j9MN9Ai-eKR5ZvzKD2McIcd03hxylBVmElWTCwCZg0Cs8rtHbPe38ZjtAITICpDigj2L8QCApSzxKbtAWVYKFe5YvA3GRxvccXaT51PP5x_EPyMfl2hNcN5ZHsjScZ4C_06euPPc0xImH7nx3VabgR_DlPoucfHPGhrbcJruV5iZ91OgNhjnn7MnvRkivdjuS_btw_vb_afs5uvHq_27m8wWDVZZhyk_tE1npAQlirpTvWhrqEuUdV-atlKiMlQQCBKqbKUyBitrCAqse4vFJXt93pui_Vwoznp00dIwGE_TEnWFqpQK_g1iI1QBSiawPoM2TDEG6vUxuNGEk0bQqxl90KsAvQrQqxl9b0bfpdGX2xtLO1L3MLipSMCrDTDp54c-ebEuPnBKYgOqTNzbM_fLDXT67wD6-st-rYrflI6p5w</recordid><startdate>200401</startdate><enddate>200401</enddate><creator>Williams, Brenda P.</creator><creator>Milligan, Carol J.</creator><creator>Street, Miyoko</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200401</creationdate><title>Transcription of the M1 muscarinic receptor gene in neurons and neuronal progenitors of the embryonic rat forebrain</title><author>Williams, Brenda P. ; Milligan, Carol J. ; Street, Miyoko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3917-d10020b9da4405238d5f2b8086148f6ab7527ae3e02e256b45aa17cae0318fc13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Differentiation - physiology</topic><topic>Cells, Cultured</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Epithelial Cells - cytology</topic><topic>Epithelial Cells - metabolism</topic><topic>Exons</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, Reporter</topic><topic>muscarinic receptor</topic><topic>neural stem cells</topic><topic>neuronal progenitor cells</topic><topic>Neurons - cytology</topic><topic>Neurons - metabolism</topic><topic>Prosencephalon - cytology</topic><topic>Prosencephalon - embryology</topic><topic>Prosencephalon - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptor, Muscarinic M1 - biosynthesis</topic><topic>Receptor, Muscarinic M1 - genetics</topic><topic>Regulatory Sequences, Nucleic Acid - physiology</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - metabolism</topic><topic>Transcription, Genetic</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, Brenda P.</creatorcontrib><creatorcontrib>Milligan, Carol J.</creatorcontrib><creatorcontrib>Street, Miyoko</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williams, Brenda P.</au><au>Milligan, Carol J.</au><au>Street, Miyoko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcription of the M1 muscarinic receptor gene in neurons and neuronal progenitors of the embryonic rat forebrain</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>2004-01</date><risdate>2004</risdate><volume>88</volume><issue>1</issue><spage>70</spage><epage>77</epage><pages>70-77</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>Development of the nervous system is accompanied by expansion and differentiation of the neuronal progenitors within the embryonic neuroepithelium. Although the role of growth factors in this process is well documented, there is increasing evidence for a role of neurotransmitters. Acetylcholine is known to exert many actions on developing neural cells, but its potential role in neurogenesis is unclear. Here, we show that the M1 muscarinic acetylcholine receptor is expressed in the neuroepithelium of the rat forebrain, where it is found on both nestin+ progenitor cells and TuJ1+ newly differentiated neurons. Furthermore, transcription is governed, at least in part, by regulatory cis elements that are also responsible for driving transcription in neuroblastoma cells. This represents the first demonstration of M1 receptors on neuronal progenitor cells and supports the notion that M1 muscarinic receptors may play a role in development of the nervous system prior to the onset of synaptogenesis and their subsequent role in neurotransmission.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>14675151</pmid><doi>10.1111/j.1471-4159.2004.02117.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of neurochemistry, 2004-01, Vol.88 (1), p.70-77 |
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| language | eng |
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| source | Wiley; Full-Text Journals in Chemistry (Open access) |
| subjects | Animals Biological and medical sciences Cell Differentiation - physiology Cells, Cultured Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Epithelial Cells - cytology Epithelial Cells - metabolism Exons Fundamental and applied biological sciences. Psychology Genes, Reporter muscarinic receptor neural stem cells neuronal progenitor cells Neurons - cytology Neurons - metabolism Prosencephalon - cytology Prosencephalon - embryology Prosencephalon - metabolism Rats Rats, Sprague-Dawley Receptor, Muscarinic M1 - biosynthesis Receptor, Muscarinic M1 - genetics Regulatory Sequences, Nucleic Acid - physiology Stem Cells - cytology Stem Cells - metabolism Transcription, Genetic Vertebrates: nervous system and sense organs |
| title | Transcription of the M1 muscarinic receptor gene in neurons and neuronal progenitors of the embryonic rat forebrain |
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