Intermittent versus maintenance iron therapy in children on hemodialysis: a randomized study

In patients with renal anemia, iron therapy can be administered intermittently or regularly at a low dose. We performed a randomized clinical trial in pediatric patients with end-stage renal failure on hemodialysis and absolute or functional iron deficiency. The study group received maintenance iron...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2004-01, Vol.19 (1), p.77-81
Main Authors: Ruiz-Jaramillo, Ma de la Cruz, Guízar-Mendoza, Juan Manuel, Gutiérrez-Navarro, María de Jesús, Dubey-Ortega, Luis Antonio, Amador-Licona, Norma
Format: Article
Language:English
Subjects:
Adolescent
Anemia, Iron-Deficiency - drug therapy
Anemia, Iron-Deficiency - etiology
Child
Diet therapy
Dosage and administration
Drug Administration Schedule
Female
Ferritins - blood
Hemodialysis
Hemoglobins - metabolism
Humans
Injections, Intravenous
Iron - administration & dosage
Iron - blood
Iron in the body
Kidney Failure, Chronic - complications
Male
Renal anemia
Transferrin - metabolism
Treatment Outcome
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Summary:In patients with renal anemia, iron therapy can be administered intermittently or regularly at a low dose. We performed a randomized clinical trial in pediatric patients with end-stage renal failure on hemodialysis and absolute or functional iron deficiency. The study group received maintenance iron therapy according to the ferritin serum levels and the control group received intermittent 10-weekly doses. Success was defined as stabilization of ferritin levels between 100 and 800 microg/l and transferrin saturation (TSAT) between 20% and 50%, in addition to an increase in the hemoglobin level. The major reason for exclusion was iron overload. The study group received 6 mg/kg per month of parenteral iron [95% confidence interval (CI) 3.3-8.8] and the control group 14.4 mg/kg per month (95% CI 12-16.8) ( P
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-003-1288-9