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Comparison of various techniques used to estimate spontaneous baroreflex sensitivity (the EuroBaVar study)
1 Institut National de la Santé et de la Recherche Médicale E107, Faculté de Médecine, 75006 Paris; 2 Laboratoire d'Exploration Fonctionnelles Vasculaires, CHU, 49033 Angers; 3 Laboratoire d'Explorations Fonctionnelles Rénales, Hôpital Jean Minjoz, 25030 Besançon; 5 CNRS UMR 5014, Facultéd...
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Published in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2004-01, Vol.286 (1), p.R226-R231 |
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Main Authors: | , , , , , , , , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
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Online Access: | Get full text |
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Summary: | 1 Institut National de la Santé et de la Recherche Médicale E107, Faculté de Médecine, 75006 Paris; 2 Laboratoire d'Exploration Fonctionnelles Vasculaires, CHU, 49033 Angers; 3 Laboratoire d'Explorations Fonctionnelles Rénales, Hôpital Jean Minjoz, 25030 Besançon; 5 CNRS UMR 5014, Facultéde Pharmacie, 69373 Lyon; 6 Laboratoire de Physiologie, Centre National de la Recherche Scientifique UMR 1523, Faculté de Médecine, 69373 Lyon, France; 4 LaRC, Unita' di Bioingegneria, Fondazione Don Carlo Gnocchi, 20148 Milano; 9 Department of Internal Medicine, University of Milano-Bicocca, II Department of Cardiology, San Luca Hospital, Istituto Auxologico Italiano, 20145 Milano; 11 Dipartimento di Scienze Precliniche, Universita' degli Studi di Milano, LITA di Vialba, 20157 Milano, Italy; 7 CARIM, Department of Pharmacology and Toxicology, 6200 Maastricht; 8 Department of Physiology, Academisch Medisch Centrum, 1105 AZ Amsterdam, The Netherlands; 10 Institut für Physiologie, Humboldt Universität, 10117 Berlin; 12 Institute of Occupational and Social Medicine, University of Technology, 01307 Dresden, Germany; and 13 Department of Exercise Science, The University of Iowa, Iowa City, Iowa 52242
Submitted 18 November 2002
; accepted in final form 12 September 2003
This study compared spontaneous baroreflex sensitivity (BRS) estimates obtained from an identical set of data by 11 European centers using different methods and procedures. Noninvasive blood pressure (BP) and ECG recordings were obtained in 21 subjects, including 2 subjects with established baroreflex failure. Twenty-one estimates of BRS were obtained by methods including the two main techniques of BRS estimates, i.e., the spectral analysis (11 procedures) and the sequence method (7 procedures) but also one trigonometric regressive spectral analysis method (TRS), one exogenous model with autoregressive input method (X-AR), and one Z method. With subjects in a supine position, BRS estimates obtained with calculations of -coefficient or gain of the transfer function in both the low-frequency band or high-frequency band, TRS, and sequence methods gave strongly related results. Conversely, weighted gain, X-AR, and Z exhibited lower agreement with all the other techniques. In addition, the use of mean BP instead of systolic BP in the sequence method decreased the relationships with the other estimates. Some procedures were unable to provide results when BRS estimates were expected to be very low in data sets (in patie |
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ISSN: | 0363-6119 1522-1490 |
DOI: | 10.1152/ajpregu.00709.2002 |