The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours

In a previous study of phyllodes tumours, it has been shown that both the stroma and the epithelium can exhibit distinct molecular changes, suggesting that both are part of the neoplastic process. In view of this finding, it was decided to study stromal–epithelial interactions in these tumours by ex...

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Bibliographic Details
Published in:The Journal of pathology 2002-04, Vol.196 (4), p.437-444
Main Authors: Sawyer, Elinor J., Hanby, Andrew M., Rowan, Andrew J., Gillett, Cheryl E., Thomas, Rachel E., Poulsom, Richard, Lakhani, Sunil R., Ellis, Ian O., Ellis, Paul, Tomlinson, Ian P. M.
Format: Article
Language:English
Subjects:
APC
beta Catenin
Biological and medical sciences
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
cyclin D1
Cyclin D1 - metabolism
Cytoskeletal Proteins - metabolism
Disease Progression
epithelial-stromal interactions
Epithelium - pathology
Female
Gynecology. Andrology. Obstetrics
Humans
Immunoenzyme Techniques
Loss of Heterozygosity
Mammary gland diseases
Medical sciences
Neoplasm Proteins - metabolism
phyllodes
Phyllodes Tumor - metabolism
Phyllodes Tumor - pathology
Proto-Oncogene Proteins - metabolism
RNA, Messenger - genetics
RNA, Neoplasm - genetics
Stromal Cells - pathology
Trans-Activators
Tumors
Wnt
Wnt Proteins
Wnt2 Protein
Zebrafish Proteins
β-catenin
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Summary:In a previous study of phyllodes tumours, it has been shown that both the stroma and the epithelium can exhibit distinct molecular changes, suggesting that both are part of the neoplastic process. In view of this finding, it was decided to study stromal–epithelial interactions in these tumours by examining the Wnt–APC–β‐catenin pathway. β‐catenin and cyclin D1 immunohistochemistry was performed on 119 phyllodes tumours. Eighty‐six (72%) showed stromal nuclear β‐catenin localization and in 57% the staining was moderate or strong; however, of the eight malignant tumours in the series, seven showed absent or weak nuclear staining (p
ISSN:0022-3417
1096-9896
DOI:10.1002/path.1067