Port of entry – the type III secretion translocon

Many Gram-negative plant and animal pathogenic bacteria use a specialized type III secretion system (TTSS) as a molecular syringe to inject effector proteins directly into the host cell. Protein translocation across the eukaryotic host cell membrane is presumably mediated by a bacterial translocon....

Full description

Saved in:
Bibliographic Details
Published in:Trends in Microbiology 2002-04, Vol.10 (4), p.186-192
Main Authors: Büttner, Daniela, Bonas, Ulla
Format: Article
Language:English
Subjects:
Animals
Bacterial Outer Membrane Proteins - chemistry
Bacterial Outer Membrane Proteins - metabolism
Bacterial Proteins - chemistry
Bacterial Proteins - metabolism
bacterial toxins
Cell Membrane - metabolism
Cell Membrane - microbiology
Cell Membrane - ultrastructure
Erythrocyte Membrane - metabolism
Erythrocyte Membrane - microbiology
Erythrocyte Membrane - ultrastructure
Gram-Negative Bacteria - metabolism
Gram-Negative Bacteria - pathogenicity
Hemolysis
Models, Biological
Molecular Chaperones - metabolism
pathogenicity
pili
Protein Binding
Protein Transport
transmembrane channels
type III effector proteins
type III secretion system
type III secretion translocon proteins
type IV secretion
Virulence
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Many Gram-negative plant and animal pathogenic bacteria use a specialized type III secretion system (TTSS) as a molecular syringe to inject effector proteins directly into the host cell. Protein translocation across the eukaryotic host cell membrane is presumably mediated by a bacterial translocon. The structure of this predicted transmembrane complex and the mechanism of transport are far from being understood. In bacterial pathogens of animals, several putative type III secretion translocon proteins (TTPs) have been identified. Interestingly, TTP sequences are not conserved among different bacterial species, however, there are structural similarities such as transmembrane segments and coiled-coil regions. Accumulating evidence suggests that TTPs are components of oligomeric protein channels that are inserted into the host cell membrane by the TTSS. How to open the door-analyses of type III translocon proteins can provide an insight into how bacterial pathogens transport effector proteins across the host cell membrane.
ISSN:0966-842X
1878-4380
DOI:10.1016/S0966-842X(02)02331-4