Role of family history and 5-HTTLPR polymorphism in female seasonal affective disorder patients with and without premenstrual dysphoric disorder

Seasonal affective disorder (SAD) and premenstrual dysphoric disorder (PMDD) share many clinical features, and have been associated with brain serotonin dysfunction. Females with SAD frequently fulfil the diagnostic criteria for PMDD. A polymorphism in the serotonin transporter promoter gene (5-HTTL...

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Bibliographic Details
Published in:European neuropsychopharmacology 2002-04, Vol.12 (2), p.129-134
Main Authors: Praschak-Rieder, Nicole, Willeit, Matthäus, Winkler, Dietmar, Neumeister, Alexander, Hilger, Eva, Zill, Peter, Hornik, Kurt, Stastny, Jürgen, Thierry, Nikolaus, Ackenheil, Manfred, Bondy, Brigitta, Kasper, Siegfried
Format: Article
Language:English
Subjects:
5-HTTLPR
Adult
Carrier Proteins - genetics
Chi-Square Distribution
Confidence Intervals
Family history
Female
Genetics
Genotype
Humans
Membrane Glycoproteins - genetics
Membrane Transport Proteins
Nerve Tissue Proteins
Odds Ratio
Polymorphism, Genetic - genetics
Premenstrual dysphoric disorder
Premenstrual Syndrome - genetics
Promoter Regions, Genetic - genetics
Regression Analysis
Seasonal affective disorder
Seasonal Affective Disorder - genetics
Serotonin - genetics
Serotonin - metabolism
Serotonin Plasma Membrane Transport Proteins
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Summary:Seasonal affective disorder (SAD) and premenstrual dysphoric disorder (PMDD) share many clinical features, and have been associated with brain serotonin dysfunction. Females with SAD frequently fulfil the diagnostic criteria for PMDD. A polymorphism in the serotonin transporter promoter gene (5-HTTLPR) has been associated with SAD. We investigated the role of family history and 5-HTTLPR in female SAD patients with and without PMDD. Forty-four SAD females with, and 43 SAD females without PMDD, were genotyped for 5-HTTLPR. Family history of affective disorders in first degree relatives was assessed. An association between the presence of PMDD and family history ( P=0.0029) and 5-HTTLPR long/short allele-heterozygosity ( P=0.033) was found in females with SAD. PMDD and SAD may share genetic vulnerability factors, one candidate gene being 5-HTTLPR. The elevated rate of affective disorders in relatives of patients with SAD and PMDD suggests higher genetic vulnerability in this subgroup when compared to patients with SAD alone.
ISSN:0924-977X
1873-7862
DOI:10.1016/S0924-977X(01)00146-8