Chronic Intestinal Inflammatory Condition Generates IL-10-Producing Regulatory B Cell Subset Characterized by CD1d Upregulation

B cells possess a variety of immune functions that are involved in normal and abnormal immune responses, including autoimmune disorders. Through murine models of intestinal inflammation, we here demonstrate a B cell subset that is induced in gut-associated lymphoid tissues and is characterized by CD...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2002-02, Vol.16 (2), p.219-230
Main Authors: Mizoguchi, Atsushi, Mizoguchi, Emiko, Takedatsu, Hidetoshi, Blumberg, Richard S, Bhan, Atul K
Format: Article
Language:English
Subjects:
Animals
Antigens, CD1 - genetics
Antigens, CD1 - immunology
Antigens, CD1d
B-Lymphocyte Subsets - immunology
CD1d antigen
Chronic Disease
Colitis - immunology
Colitis - pathology
Colon - immunology
Colon - pathology
Cytokines
Disease Progression
Female
Immune system
Interleukin-10 - biosynthesis
Interleukin-10 - genetics
Lymphoid Tissue - cytology
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Rodents
Stat3 protein
T cell receptors
Up-Regulation - immunology
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Summary:B cells possess a variety of immune functions that are involved in normal and abnormal immune responses, including autoimmune disorders. Through murine models of intestinal inflammation, we here demonstrate a B cell subset that is induced in gut-associated lymphoid tissues and is characterized by CD1d upregulation. This B cell subset appears under a chronic inflammatory environment, produces IL-10, and suppresses progression of intestinal inflammation by downregulating inflammatory cascades associated with IL-1 upregulation and STAT3 activation rather than by altering polarized T helper responses. This study indicates that B cells, by producing cytokines such as IL-10, can act as regulatory cells in immunologically mediated inflammatory reactions.
ISSN:1074-7613
1097-4180
DOI:10.1016/S1074-7613(02)00274-1