Relationships between intestinal calcium absorption, serum vitamin D metabolites and smoking in postmenopausal women

Smoking has been associated with low bone density, fractures and poor intestinal calcium absorption. Calcium absorption is a critical factor in calcium balance in postmenopausal women but the mechanisms causing decreased absorption efficiency in postmenopausal smokers are controversial and poorly de...

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Bibliographic Details
Published in:Osteoporosis international 2002-01, Vol.13 (1), p.83-88
Main Authors: Need, A G, Kemp, A, Giles, N, Morris, H A, Horowitz, M, Nordin, B E C
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Analysis of Variance
Biochemistry
Bone Density
Calcitriol - blood
Calcium, Dietary - pharmacokinetics
Cross-Sectional Studies
Female
Fractures
Humans
Intestinal Absorption
Metabolites
Middle Aged
Osteoporosis
Osteoporosis, Postmenopausal - metabolism
Parathyroid Hormone - blood
Risk Factors
Smoking
Smoking - metabolism
Vitamin D
Vitamin D - metabolism
Womens health
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Summary:Smoking has been associated with low bone density, fractures and poor intestinal calcium absorption. Calcium absorption is a critical factor in calcium balance in postmenopausal women but the mechanisms causing decreased absorption efficiency in postmenopausal smokers are controversial and poorly defined. We performed a cross-sectional study of 405 postmenopausal women attending a clinic for the management of osteoporosis to compare intestinal calcium absorption efficiency, serum vitamin D metabolites and parathyroid hormone levels in postmenopausal women who had never smoked, who were smokers previously or who were current smokers, to examine the relationships between these variables in smokers. Two hundred and fifty-two of the women had never smoked, 79 had smoked previously and 74 were current smokers. The hourly fractional rate of calcium absorption was similar in non-smokers and those who had previously smoked. Radiocalcium absorption was less in the 74 smokers compared with the 331 non-smokers [0.60 (0.29 SD) vs 0.71 (0.27); p = 0.004], as were serum calcitriol (p
ISSN:0937-941X
1433-2965
DOI:10.1007/s198-002-8342-9