Intestinal and Multivisceral Transplantation

Intestinal transplantation has been gradually instituted in the management of intestinal failure. More than 200 cases including isolated intestinal transplant, liver/intestinal transplant, and multivisceral transplant have been performed worldwide,with 1-year graft and patient survival rates of 66%...

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Bibliographic Details
Published in:World journal of surgery 2002-02, Vol.26 (2), p.226-237
Main Authors: Kato, Tomoaki, Ruiz, Phillip, Thompson, John F., Eskind, Lon B., Weppler, Deborah, Khan, Farrukh A., Pinna, Antonio D., Nery, Jose R., Tzakis, Andreas G.
Format: Article
Language:English
Subjects:
Digestive System Surgical Procedures - methods
Graft Rejection - pathology
Humans
Intestines - pathology
Intestines - transplantation
Liver Transplantation
Miami School
Multivisceral Transplantation
Patient Selection
Postoperative Care
Postoperative Complications
Short Bowel Syndrome - etiology
Short Bowel Syndrome - surgery
Survival Rate
Tacrolimus - therapeutic use
Tissue Donors
Treatment Outcome
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Summary:Intestinal transplantation has been gradually instituted in the management of intestinal failure. More than 200 cases including isolated intestinal transplant, liver/intestinal transplant, and multivisceral transplant have been performed worldwide,with 1-year graft and patient survival rates of 66% and 54%,respectively. Indications for the procedure include short bowel syndrome and functional abnormalities secondary to a variety of diseases or conditions. Tacrolimus-based immunosuppression regimens have been used universally with improved outcomes. The major contributors to the morbidity and mortality include rejection,infection, and technical complications. Of those, control of rejection remains the most difficult dilemma and it will be the key to improved patient and graft survival.
ISSN:0364-2313
1432-2323
DOI:10.1007/s00268-001-0210-5