Quetiapine attenuates the immobilization stress-induced decrease of brain-derived neurotrophic factor expression in rat hippocampus

Quetiapine is a new atypical antipsychotic drug widely used in the treatment of schizophrenia and other psychotic disorders. This study examined the influence of quetiapine on the decrease of brain-derived neurotrophic factor (BDNF) expression, induced by chronic immobilization stress, in the hippoc...

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Bibliographic Details
Published in:Neuroscience letters 2002-03, Vol.321 (1), p.65-68
Main Authors: Xu, Haiyun, Qing, Hong, Lu, Wenfu, Keegan, David, Richardson, J.Steven, Chlan-Fourney, Jennifer, Li, Xin-Min
Format: Article
Language:English
Subjects:
Animals
Antipsychotic Agents - pharmacology
Apoptosis - drug effects
Apoptosis - physiology
Biological and medical sciences
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - metabolism
Dibenzothiazepines - pharmacology
Hippocampus
Hippocampus - drug effects
Hippocampus - metabolism
Hippocampus - physiopathology
Immobilization
Immunohistochemistry
Male
Medical sciences
Nerve Degeneration - drug therapy
Nerve Degeneration - pathology
Nerve Degeneration - physiopathology
Neurons - drug effects
Neurons - metabolism
Neuropharmacology
Pharmacology. Drug treatments
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Quetiapine
Quetiapine Fumarate
Rats
Rats, Sprague-Dawley
Schizophrenia
Schizophrenia - drug therapy
Schizophrenia - pathology
Schizophrenia - physiopathology
Stress
Stress, Physiological - drug therapy
Stress, Physiological - metabolism
Stress, Physiological - physiopathology
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Summary:Quetiapine is a new atypical antipsychotic drug widely used in the treatment of schizophrenia and other psychotic disorders. This study examined the influence of quetiapine on the decrease of brain-derived neurotrophic factor (BDNF) expression, induced by chronic immobilization stress, in the hippocampus of the rat. Pretreatment with 10 mg/kg of quetiapine markedly attenuated the stress-induced decrease in levels of BDNF protein, as determined by Western blot analyses, and the reduction of BDNF immunoreactivity, in hippocampal pyramidal and dentate granular neurons. These results suggest that the chronic administration of quetiapine could be neuroprotective to hippocampal neurons in schizophrenia and this effect may be related to its antipsychotic effect in patients with schizophrenia.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(02)00034-4