A prospective study of the incidence of skin cancer and its risk factors in a Spanish Mediterranean population of kidney transplant recipients

Summary Background  Skin cancer is the most common malignancy occurring in kidney transplant recipients (KTRs). Objectives  Our purpose was to investigate, prospectively, the cumulative incidence of cancerous and precancerous skin lesions as well as their risk factors in a close follow‐up population...

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Bibliographic Details
Published in:British journal of dermatology (1951) 2003-12, Vol.149 (6), p.1221-1226
Main Authors: Fuente, M.J., Sabat, M., Roca, J., Lauzurica, R., Fernández-Figueras, M.T., Ferrándiz, C.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Biological and medical sciences
Carcinoma, Basal Cell - epidemiology
Carcinoma, Squamous Cell - epidemiology
Dermatology
Epidemiologic Methods
Female
Humans
immunosuppression
Immunosuppressive Agents - therapeutic use
Kidney Diseases - epidemiology
Kidney Diseases - surgery
Kidney Transplantation
Male
Medical sciences
Melanoma - epidemiology
Middle Aged
Precancerous Conditions - epidemiology
skin cancer
Skin Neoplasms - epidemiology
Spain - epidemiology
transplant
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:Summary Background  Skin cancer is the most common malignancy occurring in kidney transplant recipients (KTRs). Objectives  Our purpose was to investigate, prospectively, the cumulative incidence of cancerous and precancerous skin lesions as well as their risk factors in a close follow‐up population of KTRs from a Mediterranean area of Spain. Patients and methods One hundred and seventy‐four consecutive KTRs were examined at the moment of transplant and then at 6‐month intervals. The cumulative incidence of skin cancer was computed. To analyse the role of potential risk factors (age at transplantation, cause of renal failure, duration of pretransplant dialysis, type of immunosuppressive regimen, sun‐reactive skin type and history of occupational sun exposure), the Cox regression method was used. Results  After a median follow‐up of 72 months (range, 12–140), 39 patients (25·3%) developed 142 tumours [84 basal cell carcinoma (BCC) and 58 squamous cell carcinoma (SCC)]. The BCC/SCC ratio was 1·4 : 1. The cumulative incidence for skin cancer was 13% after 3 years of graft survival, increasing to 27·5% at 6 years and 48% at 10 years. Only age at the time of transplantation and occupational sun exposure had statistical significance as risk factors (P 
ISSN:0007-0963
1365-2133
DOI:10.1111/j.1365-2133.2003.05740.x