Pregnancy rates are higher with intracytoplasmic morphologically selected sperm injection than with conventional intracytoplasmic injection

To verify whether microinjection into retrieved oocytes of motile spermatozoa with morphologically normal nuclei, strictly defined by high power light microscopy (× >6000), improves the IVF/intracytoplasmic sperm injection (ICSI) pregnancy rate in couples with repeated ICSI failures. Comparative...

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Bibliographic Details
Published in:Fertility and sterility 2003-12, Vol.80 (6), p.1413-1419
Main Authors: Bartoov, Benjamin, Berkovitz, Arie, Eltes, Fina, Kogosovsky, Avraham, Yagoda, Arie, Lederman, Hanna, Artzi, Shira, Gross, Moshe, Barak, Yona
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Female
Fertilization in Vitro - methods
Gynecology. Andrology. Obstetrics
Humans
Infertility, Male - therapy
IVF/ICSI
Male
male fertility
Medical sciences
Microinjections
Oocytes - cytology
Pregnancy
Pregnancy Outcome
pregnancy rate
Sperm Count
Sperm Injections, Intracytoplasmic
sperm morphological selection
sperm nucleus
Spermatozoa - cytology
Spermatozoa - pathology
Treatment Failure
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Summary:To verify whether microinjection into retrieved oocytes of motile spermatozoa with morphologically normal nuclei, strictly defined by high power light microscopy (× >6000), improves the IVF/intracytoplasmic sperm injection (ICSI) pregnancy rate in couples with repeated ICSI failures. Comparative prospective study testing routine IVF/ICSI outcome parameters against those of modified ICSI based on morphological selection of spermatozoa with normal nuclei. Male factor fertility laboratory and IVF center. Sixty-two couples, with at least two previous consequent pregnancy failed ICSI cycles, underwent a single ICSI trial preceded by morphological selection of spermatozoa with normal nuclei. Fifty of these couples were matched with couples who underwent a routine ICSI procedure at the same IVF center and exhibited the same number of previous ICSI failures. Standard ICSI and modified ICSI. ICSI pregnancy rate. The matching study revealed that pregnancy rate after modified ICSI was significantly higher than that of the routine ICSI procedure (66.0% vs. 30.0%). Microinjection into retrieved oocytes of selected spermatozoa with strictly defined morphologically normal nuclei improves significantly the incidence of pregnancy in couples with previous ICSI failures.
ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2003.05.016