Inflammatory and Microbiologic Markers in Induced Sputum after Intravenous Antibiotics in Cystic Fibrosis

Induced sputum has been used to study airway inflammation. We sought to determine whether markers of infection and inflammation in induced sputum were a useful and safe outcome measure in cystic fibrosis. We hypothesized that bacterial density and inflammatory content of induced sputum would decreas...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2003-12, Vol.168 (12), p.1471-1475
Main Authors: Ordonez, Claudia L, Henig, Noreen R, Mayer-Hamblett, Nicole, Accurso, Frank J, Burns, Jane L, Chmiel, James F, Daines, Cori L, Gibson, Ronald L, McNamara, Sharon, Retsch-Bogart, George Z, Zeitlin, Pamela L, Aitken, Moira L
Format: Article
Language:English
Subjects:
Administration, Inhalation
Adolescent
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anti-Bacterial Agents - administration & dosage
Bacteria - isolation & purification
Biological and medical sciences
Biomarkers - analysis
Bronchial Provocation Tests - methods
Child
Colony Count, Microbial
Cystic Fibrosis - drug therapy
Cystic Fibrosis - immunology
Female
Humans
Infusions, Intravenous
Intensive care medicine
Male
Medical sciences
Saline Solution, Hypertonic - administration & dosage
Sputum - chemistry
Sputum - immunology
Sputum - microbiology
Treatment Outcome
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Summary:Induced sputum has been used to study airway inflammation. We sought to determine whether markers of infection and inflammation in induced sputum were a useful and safe outcome measure in cystic fibrosis. We hypothesized that bacterial density and inflammatory content of induced sputum would decrease after antibiotic therapy. Induced sputum was assayed for bacterial density, cell count, and differential and inflammatory markers before and after treatment with intravenous antibiotics. Fifty-five of the 72 subjects enrolled (mean age +/- SD 18.2 +/- 7.9 years) completed the study. FEV1 increased by an average 0.3 +/- 0.3 L (10.4 +/- 8.7% predicted FEV1), p
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.200306-731OC