The Relationship between Riboflavin and Plasma Total Homocysteine in the Framingham Offspring Cohort Is Influenced by Folate Status and the C677T Transition in the Methylenetetrahydrofolate Reductase Gene

Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, the methyl donor for remethylation of homocysteine to methionine. The C677T MTHFR polymorphism is associated with mild hyperhomocysteinemia, but only in the presence of low folate status. Because MTHFR c...

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Bibliographic Details
Published in:The Journal of nutrition 2002-02, Vol.132 (2), p.283-288
Main Authors: Jacques, Paul F., Kalmbach, Renee, Bagley, Pamela J., Russo, Giuseppina T., Rogers, Gail, Rosenberg, Irwin H., Selhub, Jacob, Wilson, Peter W.F.
Format: Article
Language:English
Subjects:
adenine
Biological and medical sciences
Cohort Studies
Cross-Sectional Studies
Epidemiology
Fasting
Female
folate
folic acid
Folic Acid - blood
genes
Genotype
homocysteine
Homocysteine - blood
Homocysteine - metabolism
homozygosity
Homozygote
Humans
Male
metabolism
methionine
Methylation
methylenetetrahydrofolate reductase
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Mutation
nucleotides
Nutrition
Oxidoreductases Acting on CH-NH Group Donors - genetics
Oxidoreductases Acting on CH-NH Group Donors - metabolism
people
Plasma
progeny
prostheses
Proteins
riboflavin
Riboflavin - blood
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Summary:Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, the methyl donor for remethylation of homocysteine to methionine. The C677T MTHFR polymorphism is associated with mild hyperhomocysteinemia, but only in the presence of low folate status. Because MTHFR contains flavin adenine dinucleotide (FAD) as a prosthetic group, riboflavin status may also influence homocysteine metabolism. The objective of this study was to examine the association between riboflavin status and fasting plasma total homocysteine (tHcy) concentration while also considering MTHFR C677T genotype and folate status. The study was conducted using fasting plasma samples (n = 450) from the fifth examination of the Framingham Offspring Study cohort. All persons with the TT genotype and age- and sex-matched sets of individuals with the CT and CC genotypes were selected for determination of plasma riboflavin and flavin mono- and dinucleotide levels. Plasma riboflavin was associated with tHcy concentrations, but the association was largely confined to persons with plasma folate
ISSN:0022-3166
1541-6100
DOI:10.1093/jn/132.2.283