Association between glutathione S-transferase M1 and T1 polymorphisms and increased risk for bladder cancer in Korean smokers

We evaluated the relationship between polymorphisms in the GSTM1 and GSTT1 genes and smoking status in a case-controlled study of a Korean population. The GSTM1 and GSTT1 genotypes were determined using a polymerase chain reaction (PCR)-based method and prognostic factors, such as staging and gradin...

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Bibliographic Details
Published in:Cancer letters 2003-12, Vol.202 (2), p.193-199
Main Authors: Jong Jeong, Hee, Jin Kim, Hyung, Young Seo, Il, Ju Kim, Hyun, Oh, Gyung-Jae, Cheon Chae, Soo, Sik Lim, Jung, Taeg Chung, Hun, Joong Kim, Jeong
Format: Article
Language:English
Subjects:
Antineoplastic agents
Biological and medical sciences
Bladder cancer
Carcinogens
Case-Control Studies
Confidence intervals
Deoxyribonucleic acid
DNA
Enzymes
Genes
Genetic Predisposition to Disease
Genotype
Genotype & phenotype
Glutathione Transferase - genetics
GSTM1
GSTT1
Health risk assessment
Humans
Korea
Korean
Medical sciences
Metabolites
Pharmacology. Drug treatments
Polycyclic aromatic hydrocarbons
Polymerase Chain Reaction
Polymorphism
Polymorphism, Genetic
Prognosis
Risk Factors
Smoking
Smoking - genetics
Studies
Tumors
Urinary Bladder Neoplasms - genetics
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Summary:We evaluated the relationship between polymorphisms in the GSTM1 and GSTT1 genes and smoking status in a case-controlled study of a Korean population. The GSTM1 and GSTT1 genotypes were determined using a polymerase chain reaction (PCR)-based method and prognostic factors, such as staging and grading were evaluated for 126 bladder cancer patients, and 204 control subjects. Smoking represented a high-risk factor (odds ratio (OR)=4.8, 95% confidence interval (CI)=2.9–8.0) for the patients with bladder cancer. The frequency of GSTM1 null individuals was higher than in the controls, but the differences were not statistically significant (OR=1.56, 95% CI=2.9–8.0). For Korean subjects who smoked more than 1 pack of cigarettes per year (PPY), the increased risk of bladder cancer was associated with the GSTM1 null genotype (OR=0.5, 95% CI=0.3–0.9). Low-stage bladder tumors were more common among the GSTM1 null genotypes (OR=2.3; 95% CI=1.1–5.5). This study suggests that in Korean subjects the GSTM1 null genotype may be associated with increased risk for bladder cancer, in a manner that appears to depend upon smoking status. And also, in bladder cancer patients the GSTM1 null genotype appears to be associated with a poorer prognosis with low stage bladder tumors.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2003.09.007