Dynein at the cortex

Cytoplasmic dynein is a minus end directed microtubule motor protein with numerous functions during interphase and mitosis. Recent evidence has identified several roles mediated by a fraction of cytoplasmic dynein associated with the cell cortex. So far, these include nuclear migration, mitotic spin...

Full description

Saved in:
Bibliographic Details
Published in:Current Opinion in Cell Biology 2002-02, Vol.14 (1), p.44-49
Main Authors: Dujardin, Denis L, Vallee, Richard B
Format: Article
Language:English
Subjects:
Animals
Biological Evolution
CLIP-170
cortex
Cytoskeleton - metabolism
Dynactin
Dynactin Complex
Dynein
Dyneins - physiology
LIS1
Microtubule-Associated Proteins - physiology
microtubules
Microtubules - metabolism
mitosis
Models, Biological
Molecular Motor Proteins - physiology
nuclear positioning
spindle orientation
wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cytoplasmic dynein is a minus end directed microtubule motor protein with numerous functions during interphase and mitosis. Recent evidence has identified several roles mediated by a fraction of cytoplasmic dynein associated with the cell cortex. So far, these include nuclear migration, mitotic spindle orientation, and cytoskeletal reorientation during wound healing, but others are likely. The possibility that a cortically bound form of dynein might represent its most ancient evolutionary state is discussed. Cytoplasmic dynein is a microtubule motor protein involved in many aspects
ISSN:0955-0674
1879-0410
DOI:10.1016/S0955-0674(01)00292-7