Sympathetic and brain monoaminergic regulation of energy balance in obesity-resistant rats (Lou/C)

In contrast to the Wistar rat, the Lou/C rat does not develop obesity with age. To determine the role of sympathetic output and brain monoamines in the different energy balance of Lou/C rats, the monoamine contents and activity of rate-limiting enzymes in catecholamine and serotonin biosynthesis wer...

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Bibliographic Details
Published in:Autonomic neuroscience 2003-11, Vol.109 (1), p.1-9
Main Authors: Perrin, David, Mamet, Julie, Géloën, Alain, Morel, Gérard, Dalmaz, Yvette, Pequignot, Jean-Marc
Format: Article
Language:English
Subjects:
Adipose Tissue - metabolism
Adipose Tissue, Brown - metabolism
Adipose tissues
Adrenal Glands - metabolism
Animals
Biogenic Monoamines - metabolism
Biological and medical sciences
Brain - enzymology
Brain - metabolism
Brain Stem - metabolism
Catecholamines - metabolism
Eating
Energy Metabolism
Fundamental and applied biological sciences. Psychology
Hypothalamic nuclei
Liver
Liver - metabolism
Male
Medical sciences
Metabolic diseases
Metabolism
Noradrenaline
Norepinephrine - metabolism
Obesity
Obesity - metabolism
Paraventricular Hypothalamic Nucleus - metabolism
Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ
Raphe Nuclei - metabolism
Rats
Rats, Inbred Strains
Rats, Wistar
Serotonin
Serotonin - metabolism
Sympathetic Nervous System - metabolism
Tryptophan Hydroxylase - metabolism
Tyrosine 3-Monooxygenase - metabolism
Ventromedial Hypothalamic Nucleus - metabolism
Vertebrates: nervous system and sense organs
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Summary:In contrast to the Wistar rat, the Lou/C rat does not develop obesity with age. To determine the role of sympathetic output and brain monoamines in the different energy balance of Lou/C rats, the monoamine contents and activity of rate-limiting enzymes in catecholamine and serotonin biosynthesis were assessed in brain structures involved in energy balance regulation, i.e., brainstem noradrenergic (A6, A5, A2) and serotonergic cell groups (dorsal raphe, and median raphe), and two hypothalamic nuclei (ventromedial nucleus and paraventricular nucleus). In vivo tyrosine hydroxylase activity and noradrenaline content were measured in sympathetic target organs storing fuel substrates, the liver, white adipose and brown adipose tissues in the Lou/C rat and compared to the Wistar rat. In Lou/C rats, indirect calorimetric measurements showed a higher energy expenditure despite a reduced food intake. The Lou/C rat displayed selective monoamine features. The catecholaminergic activity was higher in the white adipose tissue and interscapular brown adipose tissue but lower in the liver and adrenal gland of Lou/C rats. The noradrenergic activity in A2, A6 and ventromedial nucleus, and the serotonergic pattern in A6, dorsal raphe and median raphe were lower in Lou/C. The metabolic particularities of Lou/C rats are associated with (i) a selectively enhanced sympathetic activity restricted to the white adipose tissue and brown adipose tissue, (ii) a reduced noradrenergic activity in selective brainstem and hypothalamic areas, which control the energy expenditure and food intake.
ISSN:1566-0702
1872-7484
DOI:10.1016/j.autneu.2003.08.008