Vascular endothelial growth factor (VEGF) expression in operable gallbladder carcinomas

Aim: To investigate the angiogenic and prognostic role of vascular endothelial growth factor (VEGF) in operable gallbladder carcinomas. Methods: Sixty patients with early gallbladder carcinomas, treated with surgery alone, were investigated immunohistochemically for the expression of VEGF, thymidine...

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Bibliographic Details
Published in:European journal of surgical oncology 2003-12, Vol.29 (10), p.879-883
Main Authors: Giatromanolaki, A., Koukourakis, M.I., Simopoulos, C., Polychronidis, A., Sivridis, E.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
angiogenesis
Biological and medical sciences
Female
gallbladder carcinoma
Gallbladder Neoplasms - blood supply
Gallbladder Neoplasms - metabolism
Gallbladder Neoplasms - surgery
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Neoplasm Invasiveness
Neovascularization, Pathologic - metabolism
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Survival Analysis
Thymidine Phosphorylase - metabolism
Tumors
Vascular Endothelial Growth Factors - metabolism
VEGF
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Summary:Aim: To investigate the angiogenic and prognostic role of vascular endothelial growth factor (VEGF) in operable gallbladder carcinomas. Methods: Sixty patients with early gallbladder carcinomas, treated with surgery alone, were investigated immunohistochemically for the expression of VEGF, thymidine phosphorylase (TP) and new blood vessel formation. The results were correlated with clinico-pathological features and prognosis. Results: An increased VEGF secretion in gallbladder carcinomas was significantly associated with increased angiogenesis but not with patients survival, although high angiogenesis did relate with poor prognosis. TP was also associated with angiogenesis, but only the combined VEGF/TP expression was associated with unfavourable survival. Histological grade was another independent factor of prognosis. Conclusion: Both VEGF and TP expression are associated with high rate of angiogenesis, a factor directly associated with prognosis. The combined expression of these angiogenic factors confer a particularly poor post-operative outcome, speculature.
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2003.09.013