Pathogenesis of murine cytomegalovirus infection

Infection of mice with murine cytomegalovirus (MCMV) is an established model for studying human cytomegalovirus (HCMV) infection. Similarly to HCMV infection, pathological changes and disease manifestations during MCMV infection are mainly dependent on the immune status of the mouse host. This revie...

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Bibliographic Details
Published in:Microbes and Infection 2003-11, Vol.5 (13), p.1263-1277
Main Authors: Krmpotic, Astrid, Bubic, Ivan, Polic, Bojan, Lucin, Pero, Jonjic, Stipan
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cytomegalovirus - isolation & purification
Cytomegalovirus - pathogenicity
Cytomegalovirus - physiology
Cytomegalovirus Infections - etiology
Cytomegalovirus Infections - immunology
Cytomegalovirus Infections - physiopathology
Disease Models, Animal
Fundamental and applied biological sciences. Psychology
Human cytomegalovirus
Humans
Immune evasion
Immunosurveillance
Microbiology
Miscellaneous
Murine cytomegalovirus
Pathogenesis
Virology
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Summary:Infection of mice with murine cytomegalovirus (MCMV) is an established model for studying human cytomegalovirus (HCMV) infection. Similarly to HCMV infection, pathological changes and disease manifestations during MCMV infection are mainly dependent on the immune status of the mouse host. This review focuses mainly on the pathogenesis of MCMV infection in immunocompetent and immunodeficient and/or immature mice and discusses the principles of immunosurveillance of infection and the mechanisms by which this virus evades immune control.
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2003.09.007