Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression

Evidence of a link between genetic variation of the serotonin transporter and depression and anxiety prompted the generation of serotonin transporter knockout mice. Loss of serotonin reuptake function in knock-outs causes reduced clearance of extracellular serotonin and associated alterations in ser...

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Bibliographic Details
Published in:Biological psychiatry (1969) 2003-11, Vol.54 (10), p.953-959
Main Authors: Holmes, Andrew, Murphy, Dennis L, Crawley, Jacqueline N
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Animals
anxiety
Anxiety - genetics
Anxiety - metabolism
Behavior, Animal
Biological and medical sciences
Carrier Proteins - genetics
Carrier Proteins - metabolism
Depression
Depression - genetics
Depression - metabolism
Disease Models, Animal
gene
Humans
knockout
Medical sciences
Membrane Glycoproteins - genetics
Membrane Glycoproteins - metabolism
Membrane Transport Proteins
Methodology. Experimentation
Mice
Mice, Knockout - abnormalities
Mice, Knockout - physiology
Mood disorders
Nerve Tissue Proteins
Phenotype
polymorphism
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Serotonin Plasma Membrane Transport Proteins
Serotonin transporter
Techniques and methods
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Summary:Evidence of a link between genetic variation of the serotonin transporter and depression and anxiety prompted the generation of serotonin transporter knockout mice. Loss of serotonin reuptake function in knock-outs causes reduced clearance of extracellular serotonin and associated alterations in serotonin neuronal firing and receptor function. Behavioral phenotyping function in knock-outs revealed genetic background-related abnormalities, including increased anxiety-like behaviors, reduced aggression, and exaggerated stress responses. Ongoing studies focus on identifying environmental, genetic, and developmental factors interacting with the htt mutation to produce these abnormalities. Serotonin transporter null mutant mice provide a model system to study how genetic variation in serotonin transporter function affects risk for neuropsychiatric disease.
ISSN:0006-3223
1873-2402
DOI:10.1016/j.biopsych.2003.09.003