Enhanced contribution of NO to exercise-induced coronary responses after alpha -adrenergic receptor blockade

Department of Physiology, Faculty of Medicine, Université de Montréal, and Institut de Cardiologie de Montréal, Montréal, Québec, Canada H1T 1C8 We hypothesized that nitric oxide (NO), in addition to -adrenergic effects, may contribute to exercise-induced coronary responses after -adrenergic recepto...

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Published in:American journal of physiology. Heart and circulatory physiology 2002-02, Vol.282 (2), p.H508-H515
Main Authors: Takamura, Masayuki, Parent, Robert, Lavallee, Michel
Format: Article
Language:English
Subjects:
Adrenergic alpha-Antagonists - pharmacology
Adrenergic beta-Antagonists - pharmacology
Animals
Blood Pressure - physiology
Coronary Circulation - drug effects
Coronary Circulation - physiology
Dogs
Endothelium, Vascular - metabolism
Energy Metabolism - physiology
Enzyme Inhibitors - pharmacology
Heart Rate - physiology
NG-Nitroarginine Methyl Ester - pharmacology
Nitric Oxide - metabolism
Oxygen Consumption - physiology
Phentolamine - pharmacology
Physical Exertion - physiology
Propranolol - pharmacology
Ventricular Pressure - physiology
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Summary:Department of Physiology, Faculty of Medicine, Université de Montréal, and Institut de Cardiologie de Montréal, Montréal, Québec, Canada H1T 1C8 We hypothesized that nitric oxide (NO), in addition to -adrenergic effects, may contribute to exercise-induced coronary responses after -adrenergic receptor blockade. Data were analyzed as relationships between coronary sinus (CS) O 2 saturation (CS O 2 sat) or coronary blood flow (CBF) and myocardial O 2 consumption (M O 2 ). As M O 2 increased, CS O 2 sat fell more ( P  
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.00722.2001